CAS: 5961-59-1; 4-Methoxy-N-Methylaniline

上下游产品

4-methoxyformanilide N-(4-methoxyphenyl)-N,4-dimethylbenzenesulfonamide formaldehyd formic acidN-benzyl-N-methyl-4-methoxybenzenamine N-(4-methoxy-phenyl)-N,N'-dimethyl-thioureaN-(4-methoxy-phenyl)-N,N'-dimethyl-thiourea 2-chloro-N-(4-methoxy-phenyl)-N-methylacetamide N-[(4-chloro-phenylsulfanyl)-methyl]-N-methyl-p-anisidineN-[(4-chloro-phenylsulfanyl)-methyl]-N-methyl-p-anisidine

4'-甲氧基甲酰苯胺置于dimethyl Sulfide Borane体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,反应生成 N-甲基-P-氨基苯甲醚
参考文献:通过甲酰化-硼烷:甲基硫化物还原,对官能化伯胺进行高效且通用的n-单甲基化
标题:通过甲酰化-硼烷:甲基硫化物还原,对官能化伯胺进行高效且通用的n-单甲基化
摘要:在同一罐中用乙酸酐(afa)对官能化的芳族伯胺和脂肪族伯胺进行甲酰化,然后将硼烷:甲硫醚还原,可以得到优异的分离收率的相应n-甲胺,且不受双烷基化的影响;该反应顺序甚至适用于弱碱性和位阻胺.
DOI:10.1016/s0040-4039(00)87603-0

专利信息

专利号:US-11325912-B2
优先权日:2019-05-09
标题 :Regio-selective synthesis of imidazo[1,2-a]pyrimidines
发明人：CLAGG KYLE BRADLEY PASCUAL; WHITE NICHOLAS ANDREW; ZHANG HAIMING; GOSSELIN FRANCIS; NACK WILLIAM; O'SHEA PAUL D
权利人:GENENTECH INC
摘要:A method of regio-selectively synthesizing an imidazo-pyrimidine compound of formulae (XXa) or (XXb)comprising a step of coupling a first compound of formula XX-P1a or XX-P1b with a second compound of formula XX-P2This annulation reaction between β-ethoxy acrylamides and phosphorylated aminoimidazoles to furnish imidazo[1,2-a]pyrimidin-amines relies on steering effects from endocyclic and exocyclic phosphorylated aminoimidazoles. The reaction furnishes either 2-amino or 4-amino constitutional isomers of imidazo[1,2-a]pyrimidines with good yields and ranges of 90:10-99:1 regio-selectivity. The reaction is useful in the synthesis of various tracer molecules used in the study of neurological conditions such as where R3 and R4 together with the imidazole ring atoms to which they are bonded form a phenyl ring and the products are substituted benzimidazopyrimidines. The reaction can be generalized to form imidazo[1,2-a]pyrimidines substituted at either of their 2- and 4-positions by alkoxy or thioalkyl groups.

专利号:US-11034646-B2
优先权日:2017-09-29
标 题:Method for the synthesis of unsymmetrical tertiary amines
发明人：BOUR CHRISTOPHE; VAYER MARIE JENNY JACQUELINE; GANDON VINCENT
权利人:UNIV PARIS SACLAY; CENTRE NAT RECH SCIENT
摘要:Disclosed is a new method for the synthesis of unsymmetrical tertiary amines using alcohol and an imine, and to new tertiary amines.

专利号:US-9856205-B2
优先权日:2011-09-28
标 题:Method for the selective production of N-methyl-para-anisidine
发明人：IVANOV YURIY ALEXANDROVICH; BELIAKOV NIKOLAY GRIGORIEVICH
权利人:IVANOV YURIY ALEXANDROVICH; FROLOV ALEXANDER YURIEVICH; BELIAKOV NIKOLAY GRIGORIEVICH; IFOTOP LLC
摘要:The invention “Method for selective synthesis of N-methyl-para-anisidineâ€? relates to chemical technology processes, namely to catalytic alkylation of aromatic amines and nitro compounds. n The invention relates to the method for synthesis of N-methyl-para-anisidine (N-methyl-para-methoxyaniline; N-methyl-para-amino anisole) from para-anisidine (para-amino anisole; para-methoxyaniline) or para-nitro anisole (1-methoxy-4-nitrobenzene) and methanol in the presence of hydrogen or without hydrogen on heterogeneous catalyst. n Proposed method permits to use existing process plants used for obtaining aniline and 14-methylaniline. n The invention purpose is to provide the possibility to produce N-methyl-para-anisidine with purity at least 98% and high output that allows arrangement of highly profitable industry-scale manufacturing process.

专利号:US-9040480-B2
优先权日:2006-02-08
标题:Synthesis of glucagon-like peptide
发明人：WERBITZKY OLEG; VARRAY STÉPHANE; GIRAUD MATTHIEU; MEININGHAUS CARSTEN
权利人:LONZA AG
摘要:A new method of synthesizing GLP-1 peptide is devised.

专利号:US-4990625-A
优先权日:1982-08-31
标题 :Process for synthesis of N,N-disubstituted hydrazone
发明人：ARITA TETSUO; MABUCHI MINORU; UMEHARA SHOJI; SAKAI KIYOSHI
权利人:CANON KK
摘要:A process for synthesizing an N,N-disubstituted hydrazone comprises carrying out nitrozation by adding an aqueous solution of sodium nitrite to a solution having one part by weight of an N,N-disubstituted amine dissolved in 3 to 30 parts by weight of an organic acid, then reducing the nitrozated product to an N,N-disubstituted hydrazine by adding a reducing agent to the mixture containing the nitrozated product, and thereafter adding to the mixture containing the N,N-disubstituted hydrazine a carbonyl compound of the formula: ##STR1## wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group which may have a substituent, B represents a hydrogen atom, an alkyl group, an aryl group or an aromatic heterocyclic group, which may have a substituent, thereby performing condensation of the N,N-disubstituted hydrazine with the carbonyl compound.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.