CAS: 6300-04-5; 3-(Dimethylamino)Propanoic Acid

该化合物是一种有机化合物,其结构特征包括一种带有二甲基氨基化合物的丙酸脊椎,附于第三碳,这种化合物在室内温度下无色可粉黄液,由于有碳酸酸功能组,在水中可溶解.DMAPA展示了二甲基氨基组的基本特性,使它有可能成为有机合成和医药材料中各种应用的候选成分.它可以参与各种化学反应,包括酯化和恐吓,并经常用作其他化学化合物制作中的试剂.此外,DMAPA可作为一种表面活性剂,用于生产聚合物和涂层.安全考虑包括谨慎处理,因为它可能会刺激皮肤和眼睛,因此应当采取适当的安全措施避免接触.

结构式图片

相似化合物

14788-12-6 124072-61-3 172965-84-3

上下游产品

CAS号3853-06-3 3-(二甲氨基)丙酸甲酯 | CAS号1738-25-6 3-(二甲基氨基)丙腈 | CAS号3760-63-2 4-Dimethylamino... | CAS号69954-66-1 4-二甲基氨基丁酸盐酸盐 | CAS号124-40-3 二甲胺 | CAS号79-10-7 丙烯酸 | CAS号57-57-8 丙内酯 | CAS号50-00-0 甲醛 | CAS号107-95-9 β-丙氨酸 | CAS号63132-39-8 奥帕膦酸钠 | CAS号17268-47-2 3-(二甲基氨基)-N,N-二甲基丙酰胺

合成工艺路线路线简述

    Dimethylarsen-3-Dimethylaminopropionat 以 甲醇 作为反应溶剂,化学反应生成 N,N-二甲基-β-丙氨酸
    参考文献:ⅴ族有机金属化合物的反应.第六部分 β-丙内酯和环氧化物与二烷基氨基(二甲基)ar的开环
    标题:ⅴ族有机金属化合物的反应.第六部分 β-丙内酯和环氧化物与二烷基氨基(二甲基)ar的开环
    摘要:用二烷基氨基(二甲基)dimethyl在苯中80°处理β-丙内酯,得到由烷基-氧键裂变形成的二甲基砷3-二烷基氨基丙酸酯.二烷基氨基(二甲基)ar与1,1,1-三氯-2,3-环氧丙烷的加成反应是在环通常裂变的情况下进行的,得到2-二烷基氨基-1-三氯甲基乙氧基(二甲基)ar.尽管1-氯-2,3-环氧丙烷的反应性不如三氯化合物,但其开环方式相同.这些反应产物的降解表明氨基ar中的亲核位点是氮而不是砷原子.
    DOI:10.1039/j39710000002

    海关参考信息

    专利信息


    专利号:US-8450365-B2
    优先权日:2009-05-12
    标 题 :Efficient synthesis of galanthamine
    发明人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
    权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
    摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

    专利号:US-2007082039-A1
    优先权日:2004-10-18
    标题 :Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers, and topical gels for the transdermal delivery of steroids
    发明人:JONES GERALD S JR; ST LAURENT JOSEPH P; GOODRICH SCOTT A
    权利人:JONES GERALD S JR; ST LAURENT JOSEPH P; GOODRICH SCOTT A
    摘要:The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. The present invention also provides a novel topical gel for the transdermal delivery of steroids using the fatty alcohol esters as permeation enhancers.

    专利号:US-2015133664-A1
    优先权日:2012-06-07
    标 题:Chemical transformations of (-)-codeine to afford derivatives of codeine and morphine thereof
    发明人:MAGNUS PHILIP; GHAVIMI-ALAGHA BAHMAN
    权利人:UNIV TEXAS
    摘要:The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and overall yield of said codeine and morphine related derivatives and intermediates thereof. The present invention relates to new codeine and morphine related derivative compositions.

    专利号:US-2024182421-A1
    优先权日:2021-03-19
    标题 :Synthesis of endochin-like quinolones
    发明人:RISCOE MICHAEL K; NILSEN AARON; JIN HAIHONG; POU SOVITJ; WINTER ROLF W; DODEAN ROZALIA ANA; LIEBMAN KATHERINE M
    权利人:UNIV OREGON HEALTH & SCIENCE; US GOV VETERANS AFFAIRS
    摘要:Described herein are new synthetic routes for production of Endochin-Like Quinolone (ELQ) compounds. Synthetic routes to 3-substituted 4(1H)-quinolones are presented that are amenable to industrial scale preparation. One herein presented approach is relatively short, does not require palladium, and involves no chromatographic separation. A second herein presented approach is similarly relatively short, does not require palladium, involves no chromatographic separation, and also avoids high vacuum distillation. Additionally, both approaches require no protecting group chemistry because the insoluble 4(1H)-quinolone is not formed until the final reaction step.

    专利号:WO-2008058722-A1
    优先权日:2006-11-16
    标 题:Reagent and use thereof for the production of bisphosphonates
    发明人:LERSTRUP KNUD; PREIKSCHAT HERBERT FRITZ; FISCHER ERIK
    权利人:SANDOZ AS; LERSTRUP KNUD; PREIKSCHAT HERBERT FRITZ; FISCHER ERIK
    摘要:A new liquid reagent is disclosed in form of an ionic liquid containing phosphorous acid and a tertiary amine. The reagent can be used as a replacement of phosphorous acid, where the new reagent as a liquid reagent can be handled using usual equipment for handling liquids and the dosing of the reagent can therefore be controlled more precisely in industrial plants compared to phosphorous acid, which is a solid at ambient temperature. The new liquid reagent is particular suitable for the synthesis of bisphosphonates.

    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
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    合成参考文献


    摘要:J. Chilton and J. B. Stenlake. J. Pharm. Pharmacol. 7, 1004 (1955).
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