CAS: 6913-92-4; 1-Benzyl-3-Pyrroline

上下游产品

N,N-Di-2-Propenylbenzylamine 4383-26-0
N-Benzylbuta-2,3-Dien-1-Amine 70882-08-5
N-苄基马来酰亚胺 1-Benzyl-1H-Pyrrole-2,5-Dione 1631-26-1
苄基-2-丙炔胺 N-Propargylbenzylamine 1197-51-9

N-苄基马来酰亚胺置于红铝体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 12.0H,以95.3%的收率获得产物1-苄基-3-吡咯啉
参考文献:一种医药中间体n-苄基-3-吡咯啉的制备方法
标题:一种医药中间体n-苄基-3-吡咯啉的制备方法
摘要:本发明公开了一种医药中间体n‑苄基‑3‑吡咯啉的制备方法,所述方法包括如下步骤:将适量苄胺,顺酐,反应介质加入到反应瓶中搅拌反应得到二酰胺化合物;将二酰胺化合物溶解于四氢呋喃中,滴加适量70%红铝溶液,还原二酰胺化合物得到n‑苄基‑3‑吡咯啉.本发明原料成本低,工艺步骤简单,收率高,污染小,产品纯度高,适合工业化生产.

专利信息

专利号:US-6479668-B1
优先权日:1998-09-08
标 题 :Method of producing pyrrolidine derivatives
发明人：MURAOKA HIDEO; SATO HARUYO
权利人:TORAY INDUSTRIES
摘要:A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.

专利号:US-8030501-B2
优先权日:2006-07-28
标题 :Process for producing optically active 3-amino nitrogen-containing compounds
发明人：OHNUKI MASATOSHI; IZUMIDA MASASHI; NISHIYAMA AKIRA; MATSUMOTO SHINGO
权利人:KANEKA CORP
摘要:Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.