CAS: 875-74-1; H-D-Phg-Oh

• 英文名称H-D-Phg-Oh
• 中文名称D-(-)-α-苯基甘氨酸
• IUPAC名称(R)-2-amino-2-phenylacetic acid
• 其它别名Dα苯甘氨酸
• CAS编号875-74-1
• MFCD编号:MFCD00008061
• EINECS号:212-876-3
• FDA UNII编号:GF5LYS471N
• 分子式:C8H9NO2
• 分子量:151.17
• 产品CID: 1883650
• 产品分类有机原料→生命科学→氨基酸及其衍生物→甘氨酸及其衍生物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: ZGUNAGUHMKGQNY-SSDOTTSWSA-N
• InChI=1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)/t7-/m1/s1…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

相似化合物

物理性质

• 熔点302°C
• 沸点288.7°C at 760 mmHg
• 闪点128.4°C
• 密度1.2 g/cm3 (20°C)
• PH:-156 º (c=1,1N HCl)
• pKa:1.94±0.10(预测)
• PSA:63.32
• LogP:0.771
• 旋光度-156º(C=1,1NHCL)
• 折射率-158 ° (C=1, 1mol/L HCl)
• 蒸汽压0Pa at 25°C
• 溶解性Aqueous Acid (Sparingly), Water (Slightly, Heated)
• 外观形态白色结晶粉末
• 储存条件请置于阴暗处, 惰性气氛中,室温
• 产品应用合成半合成青霉素和头孢菌素的中间体,用于制造氨苄青霉素;氧哌嗪青霉素;头孢氨苄等.
• 性质描述白色或类白色结晶性粉末,熔点302°C.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志T
• 安全声明22-24/25-45-36/37/39-26-44-28-7-4
• 危险类别码23/24/25-36/37/38-22-20
• WGK Germany3.0

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 D-2-Phenylglycine 主要起始原料 2-Amino-2-Phenylacetonitrile
• 2835-06-5 = 875-74-1 [标题:Reaction Conditions
  标题:D(-)-α-Phenylglycine
  参考文献:Federal Republic Of Germany]
  
  6485-67-2 = 875-74-1
  反应条件:1.1 Reagents: Hydrochloric Acid,Sulfuric Acid Solvents: Water; 120 Min,Ph 8,277 K
  标题:Enzyme Distribution Derived From Macroscopic Particle Behavior Of An Industrial Immobilized Penicillin-G Acylase
  作者:Van Roon,Jeroen L.; Et Al
  参考文献:Biotechnology Progress 日期:2003 卷标:19(5) 页码:1510-1518]
  
  6485-67-2 = 875-74-1
  反应条件:1.1 Catalysts: Penicillin Amidase Solvents: Water; 4 H,Ph 7.5,25 °C
  标题:Enzyme Catalyzed Biotransformations In Aqueous Two-Phase Systems With Precipitated Substrate And/or Product
  作者:Kasche,V.; Et Al
  参考文献:Biotechnology And Bioengineering 日期:1995 卷标:45(3) 页码:261-7]
  
  33125-05-2 = 875-74-1
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 3 H,Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Ph 9
  标题:In Vitro Synthesis Of New Cyclodepsipeptides Of The Pf1022-Type: Probing The α-D-Hydroxy Acid Tolerance Of Pf1022 Synthetase
  作者:Mueller,Jane; Et Al
  参考文献:Chembiochem 日期:2009 卷标:10(2) 页码:323-328]
  
  6489-76-5 = 875-74-1
  反应条件:1.1 Reagents: Sodium Dodecylsulfonate,Sodium Nitrite,Sulfuric Acid Solvents: 1-Pentanol
  标题:Chemoenzymatic Synthesis Of D-Phenylglycine
  作者:Li,Jun; Et Al
  参考文献:Zhongguo Yaoke Daxue Xuebao 日期:2000 卷标:31(4) 页码:294-296]
  
  29125-25-5 = 875-74-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Acetic Acid,Water
  标题:The Asymmetric Synthesis Of α-Amino Acids. Electrophilic Azidation Of Chiral Imide Enolates,A Practical Approach To The Synthesis Of (R)- And (S)-α-Azido Carboxylic Acids
  作者:Evans,David A.; Et Al
  参考文献:Journal Of The American Chemical Society 日期:1990 卷标:112(10) 页码:4011-30]
  
  100-52-7 = 875-74-1
  反应条件:1.1 Reagents: Ammonium Acetate Solvents: Water; 30 Min,Ph 8,20 °C1.2 Catalysts: Nitrilase
  标题:Chemoenzymatic Method For Enantioselective Synthesis Of (R)-2-Phenylglycine And (R)-2-Phenylglycine Amide From Benzaldehyde And Kcn Using Difference Of Enzyme Affinity To The Enantiomers
  作者:Kawahara,Nobuhiro; Et Al
  参考文献:Chemcatchem 日期:2018 卷标:10(21) 页码:5014-5020]
  
  455875-26-0 = 875-74-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 3 H,110 °C
  标题:Enantioselective Hydrocyanation Of N-Protected Aldimines
  作者:Uemura,Masato; Et Al
  参考文献:Organic Letters 日期:2012 卷标:14(3) 页码:882-885]
  
  = 875-74-1
  反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water
  标题:Asymmetric Synthesis Of α-Amino Acids And α-N-Hydroxyamino Acids From N-Acylbornane-10,2-Sultams: 1-Chloro-1-Nitrosocyclohexane As A Practical [nh2+] Equipment
  作者:Oppolzer,Wolfgang; Et Al
  参考文献:Helvetica Chimica Acta 日期:1992 卷标:75(6) 页码:1965-78]
  
  188772-75-0 = 875-74-1
  反应条件:1.1 Reagents: Sodium Periodate Catalysts: Ruthenium Dioxide Solvents: Carbon Tetrachloride,Acetonitrile,Water; 30 Min1.2 2 H
  标题:Novel Enantioselective Synthesis Of Both Enantiomers Of Furan-2-Yl Amines And Amino Acids
  作者:Demir,Ayhan; Et Al
  参考文献:Helvetica Chimica Acta 日期:2003 卷标:86(1) 页码:91-105]
  
  = 875-74-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Dihydroxide Solvents: Ethanol
  标题:Asymmetric Induction. Ii. Phase Transfer-Catalyzed Reaction Of Benzaldehyde With Chloroform And Chiral Amines
  作者:Shi,Yaozeng; Et Al
  参考文献:Youji Huaxue 日期:1987 卷标:(5) 页码:350-3]
  
  6485-67-2 = 875-74-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water
  标题:Practical And Convenient Enzymatic Synthesis Of Enantiopure α-Amino Acids And Amides
  作者:Wang,Mei-Xiang; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2002 卷标:67(18) 页码:6542-6545]
  
  700-63-0 = 875-74-1
  反应条件:1.1 Reagents: Pyridoxal 5′-Phosphate Catalysts: 2-Aminohexano-6-Lactam Racemase,D-Amino Acid Amidase Solvents: Water; 24 H,Ph 8,40 °C
  标题:Enzymatic Synthesis Of Chiral Phenylalanine Derivatives By A Dynamic Kinetic Resolution Of Corresponding Amide And Nitrile Substrates With A Multi-Enzyme System
  作者:Yasukawa,Kazuyuki; Et Al
  参考文献:Advanced Synthesis & Catalysis 日期:2012 卷标:354(17) 页码:3327-3332]
  
  700-63-0 = 875-74-1
  反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Amidase Solvents: Water2.1 Reagents: Hydrochloric Acid Solvents: Water
  标题:Practical And Convenient Enzymatic Synthesis Of Enantiopure α-Amino Acids And Amides
  作者:Wang,Mei-Xiang; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2002 卷标:67(18) 页码:6542-6545]
  
  6489-76-5 = 875-74-1 [标题:Reaction Conditions
  标题:Enzymic Conversion Of N-Carbamoyl-D-Amino Acids To D-Amino Acids
  作者:Olivieri,R.; Et Al
  参考文献:Enzyme And Microbial Technology 日期:1979 卷标:1(3) 页码:201-4]
  
  1207847-57-1 = 875-74-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 70 °C; 5 Min,70 °C1.2 Reagents: Ammonium Hydroxide Solvents: Water
  标题:Resolution/deracemization Of Chiral α-Amino Acids Using Resolving Reagents With Flexible Stereogenic Centers
  作者:Soloshonok,Vadim A.; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2009 卷标:131(21) 页码:7208-7209]
  
  = 875-74-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetonitrile,Water; 20 Min,Rt1.2 Reagents: Potassium Hexafluorophosphate Solvents: Water; 20 Min,Rt
  标题:Diastereoselective Photooxidation And Reduction Of Chiral Iridium(Iii) Complexes
  作者:Li,Li-Ping; Et Al
  参考文献:Inorganic Chemistry 日期:2019 卷标:58(1) 页码:785-793]
  
  89-24-7 = 875-74-1 [标题:Reaction Conditions
  标题:Enzymic Conversion Of N-Carbamoyl-D-Amino Acids To D-Amino Acids
  作者:Olivieri,R.; Et Al
  参考文献:Enzyme And Microbial Technology 日期:1979 卷标:1(3) 页码:201-4]
  
  89-24-7 = 875-74-1 [标题:Reaction Conditions
  标题:Microbial Transformation Of Hydantoins To Amino Acids. Iii. Microbial Transformation Of Hydantoins To N-Carbamyl-D-Amino Acids
  作者:Takahashi,Satomi; Et Al
  参考文献:Journal Of Fermentation Technology 日期:1979 卷标:57(4) 页码:328-32]
  
  138-18-1 = 875-74-1 [标题:Reaction Conditions
  标题:A Stereo-Inverting D-Phenylglycine Aminotransferase From Pseudomonas Stutzeri St-201: Purification,Characterization And Application For D-Phenylglycine Synthesis
  作者:Wiyakrutta,Suthep; Et Al
  参考文献:Journal Of Biotechnology 日期:1997 卷标:55(3) 页码:193-203]
  
  188200-11-5 = 875-74-1
  反应条件:1.1 Reagents: Sodium Periodate Solvents: Carbon Tetrachloride,Acetonitrile,Water1.2 Reagents: Ruthenium Trichloride Solvents: Dichloromethane
  标题:Reversal Of The Stereochemical Course Of The Addition Of Phenylmagnesium Bromide To N-Benzylimines Derived From R-Glyceraldehyde Depending On The O-Protecting Group And Its Application To The Synthesis Of Both Enantiomers Of Phenylglycine
  作者:Badorrey,Ramon; Et Al
  参考文献:Tetrahedron 日期:1997 卷标:53(4) 页码:1411-1416]
  
  14257-84-2 + 42429-20-9 = 875-74-1
  反应条件:1.1 Reagents: Potassium Hydroxide,Cobalt Chloride (Cocl2) Catalysts: Amidase Solvents: Water; 30 Min,Ph 7.5,40 °C
  标题:Enzymic Resolution Of Dl-Phenylglycine
  作者:Machado,Georgia D. C.; Et Al
  参考文献:Process Biochemistry (Oxford 日期:2005 卷标:40(10) 页码:3186-3189]
  
  219924-26-2 = 875-74-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol
  标题:Enhanced Diastereoselectivity In The Asymmetric Ugi Reaction Using A New "Convertible" Isonitrile
  作者:Linderman,Russell J.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(2) 页码:336-337

海关参考信息

• 2902600000-乙苯
  2912110000-甲醛
  2912120000-乙醛
  2915110000-甲酸
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