CAS: 100-83-4; 3-Hydroxybenzaldehyde

相似化合物

19438-10-9 620-24-6 7781-98-8

上下游产品

CAS号6339-75-9 Methanediol,[3-... | CAS号96013-95-5 3-(叔丁基二甲基硅氧基)苯甲醛 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号1700-37-4 3-苄氧基苯甲醛 | CAS号620-24-6 3-羟基苯甲醇 | CAS号40359-32-8 3-(烯丙氧基)苯甲醛 | CAS号27004-28-0 3-(1,3-dithiola... | CAS号17119-15-2 3-羟基扁桃酸 | CAS号24393-20-2 3-(1,3-dithian-... | CAS号112116-24-2 3,3-(1,6-己烷二氧基)双苯甲醛 | CAS号108441-34-5 2-chloro-N-[3-[... | CAS号105904-51-6 1-(furan-2-yl)-... | CAS号106873-19-2 2-(3-hydroxyphe... | CAS号328062-72-2 3-((2,6-二氯苄基)氧基)苯甲醛 | CAS号50765-11-2 2-碘-5-羟基苯甲醛 | CAS号224641-82-1 3-hydroxy-2,4,6... | CAS号39515-51-0 间苯氧基苯甲醛 | CAS号588-05-6 3-(2-氨基乙基)苯酚

乙酸间甲苯酯置于磺酰氯,偶氮二异丁腈,乌洛托品,盐酸体系中,用 氯仿,乙醇,水 用作溶剂,化学反应 7.0H,以13.5 G的收率获得间羟基苯甲醛
参考文献:4-(4-溴-3-醛基-苯氧基)-苯甲腈的合成方法
标题:4-(4-溴-3-醛基-苯氧基)-苯甲腈的合成方法
摘要:本发明提供了一种4‑(4‑溴‑3‑醛基‑苯氧基)‑苯甲腈的合成方法,以3‑甲基苯酚为起始原料,与酸酐反应制备3‑甲基‑苯酯化物,3‑甲基‑苯酯化物与磺酰氯反应制备3‑氯甲基‑苯酯化物和3‑二氯甲基‑苯酯化物的混合物,加乌洛托品水解后得到3‑羟基‑苯甲醛,经溴化反应得到4‑溴‑3‑羟基‑苯甲醛,加4‑氟苯甲腈经缩合反应后制得4‑(4‑溴‑3‑醛基‑苯氧基)‑苯甲腈.本发明反应原料价廉易得,反应步骤少,生产成本低,工艺简单,产品纯度高,达99.0%以上,有利于实现工业化生产.

专利信息

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-2009131688-A1
优先权日:2007-11-21
标 题 :Method for the synthesis of 4-benzofuran-carboxylic acid
发明人：BURGOS ALAIN; MARUANI MARTINE; PERRIN FLORENCE; FREIN STEPHANE
权利人:ZACH SYSTEM
摘要:The invention concerns a novel method for synthesis of 4-benzofuran-carboxylic acid or alkyl ester thereof. n This method is characterized in that a reaction for aromatization of a compound of formula (II) is performed for the synthesis of the compound of formula (I), according to the scheme A2 below: n n n n n n n n n n wherein R independently represents hydrogen or a linear or branched C 1 - 15 alkyl group. n With the invention, it is possible to industrially synthesize 4-benzofuran-carboxylic acid or alkyl ester thereof with good yield and very good purity.

专利号:US-6524446-B2
优先权日:2001-03-27
标 题 :Process for synthesis of a porphyrin compound using a molecular sieve catalyst under microwave irradiation
发明人：KULKARNI SHIVANAND JANARDAN; RAGHAVAN KONDAPURAM VIJAYA; MOTKURI RADHA KISHAN; NAGABANDI SRINIVAS
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides an improved process for synthesis of porphyrin compounds of the general formula 1 n from pyrrole and aromatic aldehyde over zeolite molecular sieve catalysts using microwave heating, (solvent free) to provide an eco-friendly, economical, faster and selective heterogeneous method.

专利号:US-5679864-A
优先权日:1995-11-03
标题:Process for the synthesis of curcumin-related compounds
发明人：KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
权利人:GENE PRINT INC
摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

专利号:US-5763681-A
优先权日:1989-09-06
标 题 :Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
发明人：EDWARDS BROOKS; JUO RHOU-RONG
权利人:TROPIX INC
摘要:A novel synthesis of compound having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R 3 is a C 1 -C 20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula: n n (R.sup.1 O).sub.3 P n n wherein R 1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula: n n R.sup.3 OH n n wherein R 3 is as defined above, to produce a 1-alkoxy-1-aryl-methane phosphonate ester of the formula: ##STR2## reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula: ##STR3## wherein T is as defined above, to produce an enol ether of the formula: ##STR4## then oxygenating the double bond in the enol ether to give the corresponding 1,2-dioxetane compound.