专利号:US-2024228455-A1 优先权日:2021-04-27 标 题 :Synthesis of cbn and cbnv 发明人:KAVARANA MALCOLM J 权利人:TEEWINOT LIFE SCIENCES CORP 摘要:The invention includes chemical synthesis for preparing cannabinol (CBN) and cannabinovarin (CBNV). The process is suitable for inter alia the large-scale synthesis of pharmaceutical grade CBN and CBNV.
专利号:US-11719709-B2 优先权日:2020-02-14 标题 :Water soluble polymer surfactant for synthesis of functionalized polystyrene nanobeads towards detection of bilirubin in human serum 发明人:MAKKAD SARABJOT KAUR; SYAMAKUMARI ASHA 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a water soluble polymer surfactant (PS-DGlu) of formula I which is utilized for synthesis of functionalized polystyrene nanobead covalently incorporating (oligo) p-phenylenevinylene (OPV) nanosensor (PSG-OPV-n) which in turn is useful for the detection of bilirubin in human serum. The present invention further provides a process for the preparation of the water soluble polymer surfactant (PS-DGlu) of formula (I) and a mini emulsion polymerization process for the synthesis of PSG-OPV-n.wherein, n is 30-50.The PSG-OPV-n nanosensor beads show selectivity towards detection of bilirubin in presence of interferences such as glucose, sucrose, metal ions, cholesterol, and biliverdin with limit of detection of 20 nM. Ultimately, the invention also provides a kit for visual detection of bilirubin in human serum.
专利号:US-2025205370-A1 优先权日:2022-03-19 标 题:Synthesis of toluidine blue o and a kit for mucosal application 发明人:PANDA SWAGATIKA 权利人:PANDA SWAGATIKA 摘要:The present invention describes synthesis of Toluidine blue O for a formulation to be used for screening and biopsy site identification in oral cancer. The invention discloses two formulations and a method of delivery of the said formulations via a kit. The method described is a reproducible method of synthesis of pharmaceutical grade Toluidine blue O of acceptable purity and good colorimetric value. The present invention also discloses a kit that includes one formulation of a cleaning solution containing an organic acid and another formulation that is a vital stain formulation. The kit is packaged as a dual chamber sprayer having two pump dispensers, that facilitates ready to use, convenient dental chair side delivery, and allows mass screening.
专利号:US-2023339906-A1 优先权日:2020-09-26 标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof 发明人:SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD 摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
专利号:US-2023183177-A1 优先权日:2020-04-24 标题:Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds 发明人:GRILL BIRGIT; WINKLER MARGIT; SCHWAB HELMUT; STROHMEIER GERNOT; DONSBACH KAI; WALDVOGEL SIEGFRIED R; ARNDT SEBASTIAN; WEIS DOMINIK 权利人:PHARMAZELL GMBH 摘要:The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as further improved NHase enzyme mutants, nucleic acid molecules encoding these enzymes, recombinant microorganisms suitable for preparing such enzymes and mutants. Another aspect of the invention relates to a chemo-biocatalytic process for the preparation of lactam compounds comprising the new catalytic process for the preparation of alpha amino amide compounds catalyzed by NHase enzymes, as well as the chemical oxidation of the alpha amino amide by applying certain chemical oxidation catalysts suitable for converting the alpha amino amide under retention of its stereochemical configuration to the respective lactam. The novel chemo-biocatalytic process is particularly suited for the synthesis of valuable pharmaceutical compounds, like in particular (S)-Levetiracetam.
专利号:US-9724673-B2 优先权日:2011-06-30 标 题:Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles 发明人:LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE 权利人:LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE; UNIV NANTES; CENTRE NAT RECH SCIENT 摘要:A supported alkoxylated organotin reactant, to the process for preparing same, to the use of such a reactant as a catalyst for heterogeneous-phase organic synthesis, and also to a process for heterogeneous-phase synthesis of 5-substituted or 1,5-disubstituted tetrazoles using such a reactant.
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合成参考文献
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