专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-4264775-A 优先权日:1976-10-27 标 题:Synthesis of β-aminostyrenes 发明人:WHITE WILLIAM A 权利人:LILLY CO ELI 摘要:A simple process for the preparation of beta -aminostyrenes proceeds from anilines by successively diazotizing, reacting with a vinyl ester, and reacting with a secondary amine without purification of the intermediate products. The compounds are reactive enamines useful in organic synthesis.
专利号:WO-2025107145-A1 优先权日:2023-11-21 标题:Continuous synthesis method for disperse yellow dye 发明人:TAO GUOLAI; TAO ANDI; DING YONGCAI; YANG JIE; MOU ZHONGYUE 权利人:LEPING SAFELY PHARMACEUTICAL CO LTD 摘要:The present invention relates to the technical field of fine organic chemicals, and provides a continuous synthesis method for a disperse yellow dye. Continuous tubular reaction technology is used. A continuous tubular reactor provided by the present invention has a small volume, a large specific surface area, and a large heat transfer area per unit volume. The continuous tubular reactor can promptly transfer reaction heat by means of heat exchange and can ensure safety while accelerating the feeding speed. The continuous tubular reaction provided by the present invention precisely controls a raw material ratio, so that a feeding ratio of main raw materials is close to a theoretical value. In addition, by means of introducing an automatic control system, the chemical reaction can be carried out at a raw material ratio that strictly follows an optimal set value. The mass transfer and heat transfer effect of the continuous reactor is relatively good. Following the improvement to the mass transfer and heat transfer effect, the temperature control is more precise, and the generation of by-products is reduced.
专利号:US-4719053-A 优先权日:1980-08-01 标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates 发明人:SCHLAEFER LUDWIG; HAEHNLE REINHARD 权利人:HOECHST AG 摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.
专利号:US-2018370905-A1 优先权日:2013-04-05 标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
专利号:US-4257942-A 优先权日:1977-10-06 标题:New water-insoluble azo dyes 发明人:DEFEO FRANCESCO; CIPOLLI ROBERTO 权利人:ACNA 摘要:The present invention relates to the synthesis of new dyes having the following general formula: wherein: D is the residue of a diazotizable component of the carbocyclic or heterocyclic series X is an ethylene group, optionally substituted by halogen-methyl, alkyl C1-C4, aryl, aralkyl or CH2OCO(HN)nR (wherein R and n have the meanings hereinafter defined); R is alkyl C1-C8 optionally substituted by halogen, CN,COOH; aryl optionally substituted by one or more atoms of halogen, alkyl C1-C4, alkoxyl C1-C4; alkoxyl C1-C4; alkoxyl C1-C8; Aryloxy; aralkoxy; cycloalkoxy; aralkyl; naphthyl optionally substituted by halogen; alkenyl C2-C8, optionally substituted by halogen, CN, COOH; R1 and R2, either like or unlike each other, may be alkyl C1-C4 optionally substituted by halogen or CN groups; aralkyl; R3 is H; halogen, alkyl C1-C4; alkoxyl C1-C4, optionally substituted. n is 0 or 1.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 247. 摘要:Summary Tables of Biological Tests, National Research Council Chemical-Biological Coordination Center., 6(138), 1954 摘要:Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases., 25(8)(50), 1981 摘要:Schnorbach HJ et al ; Ullmann's Encyclopedia of Industrial Chemistry. 7th ed. (2005). NY, NY: John Wiley & Sons; Molluscicides. Online Posting Date: Jun 15, 2001. 摘要:US EPA; Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Benzenamine, 2-chloro-4-nitro- (121-87-9). Available from, as of October 31, 2007: https://www.epa.gov/oppt/iur/tools/data/2002-vol.html