专利号:US-5225591-A 优先权日:1992-07-28 标题 :Process for making 1-cyclopentylalyl amines useful for the synthesis of sweeteners 发明人:SWEENY JAMES G; D ANGELO LIHONG L 权利人:COCA COLA CO 摘要:The disclosed process relates to a method for preparing 1-cyclopentylalkyl amines, useful in the synthesis of artificial sweeteners, by reducing an azanorbornene in a high-yield one-step reduction of an azanorbornene, wherein the method involves use of a solvent reductant system with catalyst that is compatible with the production of edible food compositions.
专利号:US-4898952-A 优先权日:1987-05-29 标 题 :Regioselective synthesis of a 1,5-disubstituted pyrazole 发明人:MURRAY WILLIAM V; WACHTER MICHAEL P 权利人:ORTHO PHARMA CORP 摘要:A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a beta -dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls. For example, compounds of the formula (I) are formed in marked preference to isomers of formula (IV): (I) (IV)
专利号:US-9388147-B2 优先权日:2009-11-13 标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis 发明人:MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN 权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ?RL 摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
专利号:US-9394264-B2 优先权日:2009-11-13 标 题:Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis 发明人:MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA 权利人:RECEPTOS INC 摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
专利号:US-6362009-B1 优先权日:1997-11-21 标 题 :Solid phase synthesis of heterocycles 发明人:MUNOZ BENITO; CHEN CHIXU 权利人:MERCK & CO INC 摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.
专利号:US-4828849-A 优先权日:1988-01-14 标题 :Surfactant inhibition of dental plaque 发明人:LYNCH DONALD M; APPELBAUM BENJAMIN 权利人:WARNER LAMBERT CO 摘要:The invention provides an oral preparation or composition such as a mouthwash, mouthrinse, toothpaste and the like containing certain classes of surfactants which act to inhibit plaque formation by inhibiting the initial adherence of bacteria to the dentin surfaces and in the case of one class of surfactants additionally inhibiting the glucosyl transferase catalysis to prevent the synthesis of extracellular polysaccharides from sucrose. n The surfactants comprise substituted taurines, substituted isethionates and substituted hydroxy sultaines in which the substituents are long chain hydrocarbon radicals. The surfactants are employed in the aqueous-based oral compositions at concentrations between about 0.00001M to 0.1M to effect inhibition.
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 参考文献:10.1007/s00784-004-0262-7 摘要:De Menezes M, Turssi CP, Hara AT, Messias DC, Serra MC. Abrasion of eroded root dentine brushed with different toothpastes. Clin Oral Investig. 2004 Sep;8(3):151–5. doi: 10.1007/s00784-004-0262-7. 参考文献:10.2116/analsci.20.879 摘要:Absalan G, Soleimani M. Simultaneous determination of aniline and cyclohexylamine by principal component artificial neural networks. Anal Sci. 2004 May;20(5):879–82. doi: 10.2116/analsci.20.879. 参考文献:10.1007/s00424-012-1196-6 摘要:Reimold FR, Stewart AK, Stolpe K, Heneghan JF, Shmukler BE, Alper SL. Substitution of transmembrane domain Cys residues alters pHo-sensitive anion transport by AE2/SLC4A2 anion exchanger. Pflügers Archiv - European Journal of Physiology. 2012 Dec 28;465(6):839–51. doi: 10.1007/s00424-012-1196-6. 参考文献:10.1186/s12992-015-0127-7 摘要:Schram A, Labonte R, Baker P, Friel S, Reeves A, Stuckler D. The role of trade and investment liberalization in the sugar-sweetened carbonated beverages market: a natural experiment contrasting Vietnam and the Philippines. Globalization and Health. 2015 Oct 12;11(1):41. doi: 10.1186/s12992-015-0127-7.