CAS: 1445-45-0; Trimethyl Orthoacetate

上下游产品

CAS号79-20-9 乙酸甲酯 | CAS号149-73-5 原甲酸三甲酯 | CAS号67-56-1 甲醇 | CAS号60-29-7 乙醚 | CAS号82190-86-1 1-((2-chloroeth... | CAS号594-72-9 二氯硝基乙烷 | CAS号124-41-4 甲醇钠 | CAS号14777-27-6 甲基乙酰亚胺酯 盐酸盐 | CAS号922-69-0 1,1-二甲氧基乙烯 | CAS号75-07-0 乙醛 | CAS号105020-38-0 1-甲基-1,2,3-三氮唑-... | CAS号105020-39-1 2-甲基-1,2,3-三氮唑-... | CAS号106500-93-0 N,N'-di(propan-... | CAS号312600-96-7 6-氟-2-甲基苯并噁唑 | CAS号56038-13-2 三氯蔗糖 | CAS号5380-42-7 2-噻吩甲酸甲酯 | CAS号3363-56-2 2,5,6-三甲基苯并咪唑 | CAS号329-59-9 4-氟-3-硝基苯甲酸甲酯 | CAS号3943-74-6 香草酸甲酯 | CAS号627-40-7 烯丙基甲基醚

甲醇,乙腈置于盐酸,氨体系中,用 均三甲苯 用作溶剂,化学反应 16.0H,以87%的收率获得原乙酸三甲酯
参考文献:一种高品质原乙酸三甲酯的生产工艺
标题:一种高品质原乙酸三甲酯的生产工艺
摘要:本发明公开了一种高品质原乙酸三甲酯的生产工艺,在溶剂偏三甲苯存在下,采用乙腈,甲醇,氯化氢经成盐反应制备乙亚胺甲醚盐酸盐,然后置于甲醇溶液中,滴加氨甲醇液调节ph值,进行醇解反应得到原乙酸三甲酯粗品,过滤除固体氯化铵并回收利用,滤液经强碱性大孔离子交换树脂吸附除氯离子,最后通过连续精馏获得含量大于99.5%,收率大于85%的原乙酸三甲酯产品.本发明工艺简单,产品稳定可靠,使用的偏三甲苯溶剂低毒,使用安全.

专利信息

专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人：HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-8598346-B2
优先权日:2008-07-16
标 题 :Synthesis of cyclic amidines
发明人：LENTZEN GEORG; NEUHAUS THORSTEN
权利人:LENTZEN GEORG; NEUHAUS THORSTEN; BITOP AG
摘要:The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a β-, γ- or δ-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.

专利号:WO-0056721-A1
优先权日:1999-03-23
标题 :Solid phase synthesis of benzodiazepine diones
发明人：DENER JEFFREY MARK
权利人:AXYS PHARM INC; DENER JEFFREY MARK
摘要:The present invention provides a process for the synthesis of a compound or an array of compounds of formula (I). Compounds of formula (I) generally represent the therapeutically important class of compounds namely diversely substituted benzodiazepine diones.

专利号:US-4256646-A
优先权日:1978-06-29
标题:Synthesis of optically pure thromboxanes
发明人：HERNANDEZ OSCAR; BEND JOHN R; ELING THOMAS E; MCKINNEY JAMES D
权利人:US HEALTH EDUCATION & WELFARE
摘要:In an elegant stepwise process for the production of intermediates of thromboxanes such as TXB 2 from a chiral glucose starting material such as α-methylglucoside, those steps comprising: ##STR1## A key modification introduced in this synthetic sequence is the use of 4-dimethylaminopyridine for the selective alkylation of primary alcohols in the presence of unprotected secondary alcohols and for the controlled acylation of methylglucoside. The former application has large potential use in the synthesis of nucleosides, polynucleotides, and carbohydrate derivatives.

专利号:US-4219489-A
优先权日:1978-09-05
标题:Synthesis of steroids
发明人：BUNES LEONARD A; JOHNSON WILLIAM S
权利人:STANFORD LELAND JUNIOR UNIV TR
摘要:Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and having a terminating group involving pi unsaturation (a double or triple bond) conjugated to an aromatic ring. Upon acid catalysis, sigma bonds are formed through the interaction of a carbocation formed at the carbon atom bonded to the chalcogen atom and the double bond intermediate the initiating group and the terminating group, which close to form rings of a steroid nucleus, the carbocation interacting with the pi unsaturation conjugated with the aromatic group and being captured by a nucleophile present in the acidic reaction medium. The resulting steroid product may then be modified in known ways to produce known steroids.