专利号:US-3558614-A 优先权日:1967-09-05 标题:Synthesis of tetranuclear dyes 发明人:JENKINS PHILIP W 权利人:EASTMAN KODAK CO 摘要:TETRANUCLEAR DYES DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4-THIONE AND A 2-IMIDAZOLIN-4-SELENONE ARE PREPARED IN GOOD YIELDS BY CONDENSING A QUATERNIZED MEROCYANINE DYE DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4-THIONE OR A 2-IMIDAZOLIN4-SELENONE WITH (1) A DIALKOXYALKYL ESTER OF AN ORGANIC ACID, (2) A TRIALKOXY ALKANE OR ARYL COMPOUND, (3) A 3,3-DIALKOZY-1ALKOXYPROPENE, (4) A 1-ANILINO-5-PHENYLIMINO-1,3-PENTADIENE OR (5) A SECOND QUATERNIZED MROCYANINE DYE DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4THIONE OR A 2-IMIDAZOLIN-4-SELENONE, EACH HAVING SUBSTITUTED ON THE CARBON IN THE 2-POSITION A GROUP SUCH AS A B-ACETANILIDOVINYL GROUP, A 4-ACETANILIDO-1,3-BUTADIENYL GROUP, AND A 6-ACETANILIDO-1,3,5-HEXADIENYL GROUP.
专利号:US-2006004188-A1 优先权日:2000-09-29 标 题:Intermediates and the synthesis of modified carbocyanine dyes and their conjugates
专利号:US-2017158858-A9 优先权日:2013-03-07 标 题:Cyanine compounds 发明人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G 权利人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G 摘要:Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
专利号:US-11053222-B2 优先权日:2010-12-21 标 题 :Fluorescent compounds 发明人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA; LEHMANN FRANK G 权利人:PIERCE BIOTECHNOLOGY INC; DYOMICS GMBH 摘要:Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
专利号:US-7566790-B2 优先权日:2000-09-29 标 题 :Intermediates and the synthesis of modified carbocyanine dyes and their conjugates
专利号:US-10696653-B2 优先权日:2012-03-02 标 题:Cyanine compounds 发明人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G; NLEND MARIE CHRISTINE 权利人:PIERCE BIOTECHNOLOGY INC; DYOMICS GMBH 摘要:Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
[参考文献]: Natalia G Zhegalova, Et Al. Minimization Of Self-Quenching Fluorescence On Dyes Conjugated To Biomolecules With Multiple Labeling Sites Via Asymmetrically Charged Nir Fluorophores. Contrast Media Mol Imaging. 2014 Sep-Oct;9(5):355-62.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).