CAS: 251085-87-7; Methyl 5-Bromo-2-Chlorobenzoate

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CAS号67-56-1 甲醇 | CAS号21739-92-4 5-溴-2-氯苯甲酸 | CAS号21900-52-7 5-溴-2-氯苯甲酰氯 | CAS号79-37-8 草酰氯 | CAS号28077-43-2 2-chloro-5-(2-m... | CAS号189628-37-3 5-溴-2-氯苯甲醛 | CAS号149965-40-2 5-溴-2-氯苯甲醇 | CAS号625470-33-9 2-氯-5-(4,4,5,5-...

5-溴-2-氯苯甲酸 以98的收率获得2-氯-5-溴苯甲酸甲酯
参考文献:Combination Therapies Utilizing Benzamide Inhibitors Of The P2X7 Receptor
标题:Combination Therapies Utilizing Benzamide Inhibitors Of The P2X7 Receptor
摘要:本发明提供了治疗il-1介导疾病的方法,包括给予来自以下药物组的药物剂量:磺胺嘧啶,他汀类,糖皮质激素类,P38激酶抑制剂,抗il-6受体抗体,阿那西单,Il-1单克隆抗体,Jak3蛋白酪氨酸激酶抑制剂,M-Csf单克隆抗体或人源化抗cd20单克隆抗体以及p2X7受体苯甲酰胺抑制剂,其化学式如下:其中r1-R3定义如本文所述.本发明的方法在治疗il-1介导的疾病中非常有用,包括但不限于炎症性疾病,如骨关节炎和类风湿性关节炎;过敏,哮喘,慢性阻塞性肺疾病,癌症,再灌注或缺血性中风或心脏病,自身免疫性疾病和其他疾病.

专利信息

专利号:US-7951827-B2
优先权日:2005-05-05
标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
发明人：TIDWELL RICHARD R; BAKUNOVA SVETLANA M; BAKUNOV STANISLAV; PATRICK DONALD A
权利人:UNIV NORTH CAROLINA
摘要:Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

专利号:US-2006264487-A1
优先权日:2005-05-05
标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

专利号:AU-2006201739-A1
优先权日:2005-05-05
标题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

专利号:EP-1719767-A1
优先权日:2005-05-05
标题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

专利号:CA-2545778-A1
优先权日:2005-05-05
标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

专利号:CN-1869027-A
优先权日:2005-05-05
标 题:Synthesis and Antiprotozoal Activity of Dicationic 3,5-Diphenylisoxazoles