CAS: 3371-27-5; (2S,3R)-2-(3,4,5-Trihydroxyphenyl)Chromane-3,5,7-Triol

上下游产品

(2R,2''R,3S,3''R,4S)-[4,8]-2,3-trans-3,4-trans-(+)-catechin-(-)-epigall°C atechin (-)-epigall°C atechin 3,4'-di-O-gallate (-)-epigall°C atechin 3,3'-di-O-gallate (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate oolongtheanine theasinensin C LDN-0096693 LDN-0096568

(-)-表没食子儿茶素 以 水 用作溶剂,化学反应 1.0H,以63%的收率获得(-)-倍儿茶酸
参考文献:Epimerization Of Tea Catechins Under Weakly Acidic And Alkaline Conditions
标题:Epimerization Of Tea Catechins Under Weakly Acidic And Alkaline Conditions
摘要:在ph 7的缓冲溶液中,用n2代替o2,在80 oc下,茶叶儿茶素迅速发生差向异构化反应,氧化副反应不到10%,儿茶素差向异构体的收率为50-63%.具有三个羟基的儿茶素比具有两个羟基的儿茶素差向异构化反应更快,不含没食子酰基的儿茶素比含有没食子酰基酯的儿茶素差向异构化反应更快.
Doi:10.1271/bbb.90884

专利信息

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-9428482-B2
优先权日:2011-01-27
标 题 :Process for synthesis of polyphenols
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE; SPHAERA PHARMA PTE LTD
摘要:The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.

专利号:US-2016361291-A1
优先权日:2013-12-18
标 题:Methods for increasing skeletal muscle protein synthesis using green tea extract
发明人：MEADOR BENJAMIN; PEREIRA SUZETTE; EDENS NEILE; TISDALE MICHAEL
权利人:ABBOTT LAB
摘要:Methods of increasing skeletal muscle protein synthesis in a subject are provided. Methods of increasing or maintaining mammalian target of rapamycin (mTOR) activation are also provided. Such methods include a step of administering at least one serving per day of a composition including 20 to 2,000 mg of a green tea extract per serving to the subject.

专利号:JP-2020117531-A
优先权日:2013-01-26
标题 :Novel process for synthesis of catechins

专利号:US-2009170928-A1
优先权日:2005-04-28
标题:Synthesis of oligo/poly(catechins) and methods of use

专利号:US-2014031421-A1
优先权日:2011-01-27
标 题 :Novel process for synthesis of polyphenols