专利号:US-11753440-B2 优先权日:2018-06-05 标题 :Methods for the synthesis of arginine-containing peptides 发明人:HEIDL MARC; GEOTTI-BIANCHINI PIERO 权利人:DSM IP ASSETS BV 摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a deprotection step that minimizes the transfer of by-products deriving from cleaved sulfonyl-5 based side chain protecting groups from arginine to amino acids carrying electron rich side chains.
专利号:US-9402895-B2 优先权日:2007-08-15 标题:Method of enhancing KSHV LANA1 immunogenicity 发明人:CHANG YUAN; MOORE PATRICK S 权利人:CHANG YUAN; MOORE PATRICK S; UNIV OF PITTSBURG—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 摘要:An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1â€?) polypeptide and related methods of eliciting an immune response to KSHV LANA1 are provided. Also described herein is a novel polypeptide capable of inhibiting degradation of a protein or retarding synthesis of a protein when attached to or incorporated within that protein.
专利号:US-2008311580-A1 优先权日:2004-03-09 标 题:Novel genes encoding proteins involved in proanthocyanidin synthesis 发明人:ABRAHAMS SHARON; ASHTON ANTHONY RICHARD; TANNER GREGORY JOHN; LARKIN PHILIP JOHN 权利人:COMMW SCIENT IND RES ORG 摘要:This inventions provides an isolated protein or polypeptide having activity in the synthesis of proanthocyanidin (PA) polymer from epicatechin or catechin in plants, and which is not naturally regulated by the TT2 or TT8 regulators, or a fragment comprising at least about 10 contiguous amino acids derived from said protein or polypeptide, particularly TDS1, TDS2, TDS3, TDS4, TDS5, or TDS6 protein, or fragment thereof. n Also provided are nucleic acid encoding such proteins or polypeptides; plant cells and plants containing and expressing such nucleic acids; antibodies that bind to such proteins or polypeptides; and related methods.
专利号:US-2012208198-A1 优先权日:2007-01-11 标 题:Novel gene encoding myb transcription factor involved in proanthocyanidin synthesis 发明人:BOGS JOCHEN; WALKER AMANDA RUTH; ROBINSON SIMON PIERS 权利人:BOGS JOCHEN; WALKER AMANDA RUTH; ROBINSON SIMON PIERS; COMMW SCIENT IND RES ORG 摘要:An isolated or recombinant MYB polypeptide having activity as a transcription factor in the synthesis of proanthocyanidins in plants, and nucleic acid molecule encoding same, wherein the polypeptide activates in the plants (a) promoters of the leucoanthocyanidin (LAR) and anthocyanidid reductase (ANR) genes, and (b) promoters of at least two of the genes of the general flavonoid pathway. Use of the polypeptide and nucleic acid molecule in regulating the biosynthesis and accumulation of proanthocyanidins in plants, such as in modifying pasture quality of legumes, is also disclosed.
专利号:US-5369017-A 优先权日:1994-02-04 标题 :Process for solid phase glycopeptide synthesis 发明人:WONG CHI-HUEY; SCHUSTER MATTHIAS 权利人:SCRIPPS RESEARCH INST 摘要:A process for the synthesis of a glycopeptide using a solid phase matrix is disclosed. The matrix is compatible with aqueous and organic solvents and is comprised of a silica-based solid support to which is linked a two-part spacer group having a chain length of about 12 to about 40 methylene groups. The first part of the spacer is covalently bonded to the silica-based support and has a length of about 3 to about 10 methylene groups. The second spacer part is covalently bonded to the first part of the spacer and comprises the distal end of the two part spacer. The second part is soluble as a free molecule in each of water, dimethylformamide and dichloromethane and has a terminal amine or hydroxyl group to which the C-terminal residue of the peptide portion of the glycopeptide chain is bonded. The chain of atoms connecting the desired glycopeptide to the solid phase matrix also includes a moiety having a selectively severable bond which on cleavage of that bond separates the matrix from whatever else is bonded to that moiety.
专利号:US-2023212216-A1 优先权日:2019-12-20 标 题:Synthesis of lactone derivatives and their use in the modification of proteins 发明人:MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH 权利人:GENIE BIOTECH UK LTD 摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.
参考标题:Coupling-Reagent-Free Synthesis Of Dipeptides And Tripeptides Using Amino Acid Ionic Liquids 作者:Shinya Furukawa,Takahide Fukuyama,Akihiro Matsui,Mai Kuratsu,Ryotaro Nakaya,Takashi Ineyama,Hiroshi Ueda,Ilhyong Ryu |发布日期:2015.8.17 摘要:Method For The Synthesis Of Dipeptides Has Been Developed, Which Does Not Require Any Coupling Reagents. This Method Is Based On The Reaction Of Readily Available Hcl Salts Of Amino Acid Methyl Esters With Tetrabutylphosphonium Amino Acid Ionic Liquids. The Isolation Procedure Of Stepwise Treatment With Acoh Is Easy To Carry Out. The Method Was Extended To The Synthesis Of Tripeptide, Tyrosyl‐glycyl‐glycine
合成参考文献
参考文献:10.1107/s2052520620002917 摘要:Jha KK, Gruza B, Kumar P, Chodkiewicz ML, Dominiak PM. TAAM: a reliable and user friendly tool for hydrogen-atom location using routine X-ray diffraction data. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2020 Jun 01;76(Pt 3):296–306. doi: 10.1107/s2052520620002917. 摘要:Compound: L-Alanine, N-glycyl-, homopolymer