CAS: 480-16-0; 2-(2,4-Dihydroxyphenyl)-3,5,7-Trihydroxy-4H-Chromen-4-One

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CAS号1707-75-1 1,1-二苯基-2-苦味酰肼 | CAS号89-86-1 2,4-二羟基苯甲酸 | CAS号144-62-7 草酸 | CAS号108-73-6 间苯三酚 | CAS号108-46-3 间苯二酚 | CAS号7555-80-8 Pentamethoxymorin

2-(2,4-Dimethoxyphenyl)-3-Hydroxy-5,7-Dimethoxy-4H-Chromen-4-One置于氢溴酸,溶剂黄146体系中,用 甲醇,水 作为反应溶剂,以94 %的收率获得产物桑色素
参考文献:黄酮醇莫林的多糖,无色谱合成
标题:黄酮醇莫林的多糖,无色谱合成
摘要:描述了一种廉价的五步合成 40 G 规模的黄酮醇桑酚,这是一种用于电镀过程的天然产物.对查耳酮前体与碱性叔丁基过氧化氢 (Tbhp)氧化环化得到的产物进行了综合分析.首次表征了四甲基桑碱的金醛醇异构体,其优选羟基苯并呋喃互变异构体.表明至少部分由相应的金酮形成金醛酚.我们能够设计出一种后处理顺序,避免所有反应步骤使用工业级溶剂进行色谱法.从n中重结晶粗 Tbhp 氧化产物-丁醇允许去除除四甲基桑色素和异构的金桂醇之外的所有组分,它们以钠盐的形式分离.
DOI:10.1021/acs.Oprd.3C00020

专利信息

专利号:US-9676886-B2
优先权日:2014-08-08
标 题 :One-pot synthesis of flexible poly-p-(phenyleneethynylene)s with controlled conjugated length
发明人：MOON JOONG HO; VOKATA TEREZA
权利人:MOON JOONG HO; VOKATA TEREZA; UNIV FLORIDA INT
摘要:A novel monomer design for the synthesis of PPE-type polymers containing conjugated segments of well-defined length connected by flexible linkers under Sonogashira reaction conditions is presented. The resulting polymers retain the photophysical properties of a fully conjugated PPE. The extent of incorporation of the flexible units along the backbone is governed by the comonomer feed ratio and can be varied in a statistically predictable fashion.

专利号:WO-2016122325-A1
优先权日:2015-01-30
标 题:Methods for providing intermediates in the synthesis of atorvastatin.
发明人：DÖMLING ALEXANDER STEPHAN SIEGFRIED
权利人:UNIV GRONINGEN
摘要:The invention relates to the field of medicinal chemistry, In particular, it relates to methods for providing intermediates in the synthesis of Atorvastatin, a competitive inhibitor of HMG-Co A reductase. Provided is a process for providing a compound having a Formula (I) or a pharmaceutically acceptable salt, ester, amide or stereoisomer thereof, comprising reacting in a 4 component Ugi-reaction in a single reaction mixture the compounds of formula A, formula B, formula C and formula D.

专利号:US-5043328-A
优先权日:1986-05-09
标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
发明人：WEITHMANN KLAUS U
权利人:HOECHST AG
摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-2023104375-A1
优先权日:2021-10-01
标题 :Method for multiplexable strand-specific 3' end sequencing of mrna transcriptome primer set, kit and application thereof
发明人：PAN XINGHUA; Mai Liyao; CHEN CAIMING; Qiu Yinbing; LIAN ZHIWEI
权利人:SEQUMED BIOTECHNOLOGY INC; DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY SOUTHERN MEDICAL UNIV
摘要:The invention discloses a primer set and a multiplexable library building scheme for constructing an RNA sequencing library with a related reagent kit and an application thereof. The invention also discloses a corresponding data analysis method and a related instrument. The primer set used for RNA sequencing library construction includes the reverse transcription primers containing poly-dT, the 2nd strand cDNA primers particularly contain a random or semi-random portion at their 3′ end for universal initiation of the synthesis at multiple sites, or sequence capturing the 1st strand of a specific cDNA, as well as their corresponding PCR primer 1 and 2. By this method, the library construction process is simple and the operation is convenient; the time of building the database was significantly shortened; it can carry out a large number of samples in a single run; the analysis process is simpler; the cost of database building, sequencing and analysis is significantly reduced.