CAS: 535-83-1; 1-Methylpyridin-1-Ium-3-Carboxylate

该化合物是天然存在的碱性碱,主要存在于咖啡豆,fenugreek种子和各种其他植物中,是硝基苯(vitamin B3)的衍生物,以其在植物代谢作用著称.Trigonelline是一种在水和酒精中溶解但非极溶剂中溶解的,白到白的黄晶状粉.它的化学配方是C7H77N1O3,其分子重量约为155.14克/摩尔.这种复合物展示了各种生物活动,包括潜在的抗糖尿病,抗炎和...

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合成工艺路线路线简述

    3-Carboxy-1-Methylpyridiniumiodid置于水,Silver(L) Oxide体系中,化学反应生成 葫芦巴碱
    参考文献:Kirpal,Monatshefte Fur Chemie,1901,Vol. 22,P. 373
    标题:Kirpal,Monatshefte Fur Chemie,1901,Vol. 22,P. 373

    海关参考信息

    专利信息


    专利号:US-2005176827-A1
    优先权日:2002-05-10
    标 题:Compositions and methods for glycogen synthesis
    发明人:LEE STEVE S; HYNSON RICHARD B; RUBY BRENT C; GASKILL STEVEN E
    摘要:A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning. Preferably, the composition of bio-active compounds includes a combination of 4-hydroxyisoleucine with at least one amino acid selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, gamma-amino butyrate and tyrosine. In one presently preferred embodiment of the present invention, the combination is derived, isolated, and/or extracted from fenugreek seeds. Methods for using a novel composition of bio-active compounds from fenugreek seed for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning are also disclosed, wherein methods comprise the steps of: (1) providing an effective amount of a composition of bio-active compounds derived, isolated, and/or extracted from fenugreek seeds; and (2) administering the composition to a human or animal.

    专利号:WO-0007607-A1
    优先权日:1998-08-04
    标 题:Nutrient and therapeutic compositions for the treatment of cancer
    权利人:KOSBAB JOHN V
    摘要:This invention relates to nutrient and therapeutic compositions for the treatment of cancer symptoms and conditions. Compositions of this invention contain a mixture of antioxidants, components that promote collagen maintenance and synthesis, components that regulate blood lipids, glucose and/or insulin, and lower homocysteine levels. Compositions also provide supplementation for nutrient (vitamin, mineral and cofactor) deficiencies to restore and maintain normal biochemical function. Cancer formulations, particularly those adapted for treatment of female cancers, can be combined with components that provide benefit in osteoporosis.

    专利号:US-11661349-B2
    优先权日:2019-09-05
    标题 :Method for making coffee husk reducing agent
    发明人:MOHAMED HANAN HUSSEIN AMIN; HAMMAMI INES MOHSEN; MOUSTAFA TAMER EZZAT YOUSSEF
    权利人:UNIV IMAM ABDULRAHMAN BIN FAISAL
    摘要:An efficient green method for the synthesis of noble metal/transition metal oxide nanocomposite comprising reducing noble metal salt and a templating metal oxide is disclosed. The method is a one-step method comprises mixing coffee seed husk extract, a noble metal precursor, and a transition metal precursor; and filtering and drying the nanocomposite. The nanocomposite prepared by the method of the invention displays all the characteristics and biocidal activity of a composite prepared by traditional methods.

    专利号:US-8945508-B2
    优先权日:2009-10-13
    标 题 :Dendrimer compositions and methods of synthesis
    发明人:BAKER JR JAMES R; HUANG BAOHUA
    权利人:BAKER JR JAMES R; HUANG BAOHUA; UNIV MICHIGAN
    摘要:The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).

    专利号:EP-1493431-B1
    优先权日:2003-07-03
    标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions
    发明人:WIRTH CORINNA DR; BUCHHOLZ HERWIG DR
    权利人:MERCK PATENT GMBH
    摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.

    专利号:US-4093622-A
    优先权日:1975-05-19
    标题 :Pyridine esters of cyclopropane-carboxylic acid
    发明人:HENRICK CLIVE A; STAAL GERARDUS B
    权利人:ZOECON CORP
    摘要:Heterocyclic organic esters and thioesters characterized by the presence of one or two cyclopropane moieties, synthesis thereof, and compositions thereof for the control of mites and ticks.
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