CAS: 5451-09-2; 5-Amino-4-Oxopentanoic Acid Hydrochloride

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CAS号839724-53-7 diethyl 2-acety... | CAS号159150-70-6 methyl 5-azido-... | CAS号93393-93-2 5-乙酰基氨基戊酮酸甲酯 | CAS号109258-71-1 methyl 5-(1,3-d... | CAS号155585-41-4 5,5-dimethoxy-2... | CAS号53856-93-2 4-氧代-5-溴戊酸甲酯 | CAS号142-08-5 2-羟基吡啶 | CAS号487-90-1 胆色素原 | CAS号79416-27-6 5-氨基酮戊酸甲酯盐酸盐 | CAS号106-60-5 5-氨基乙酰丙酸 | CAS号72072-06-1 5-((叔丁氧基羰基)氨基)-... | CAS号77479-02-8 2,5-吡嗪二丙酸 | CAS号77479-03-9 3,3'-(3,6-dihyd...

2-四氢糠胺置于盐酸,Ruthenium Trichloride,Sodium Periodate体系中,用 四氯化碳,氯仿,水,乙腈 作为反应溶剂,化学反应 11.0H,反应生成 5-氨基乙酰丙酸盐酸盐
参考文献:Kawakami,Hiroshi; Ebata,Takashi; Matsushita,Hajime,Agricultural And Biological Chemistry,1991,Vol. 55,# 6,P. 1687-1688
标题:Kawakami,Hiroshi; Ebata,Takashi; Matsushita,Hajime,Agricultural And Biological Chemistry,1991,Vol. 55,# 6,P. 1687-1688

专利信息

专利号:US-2024117387-A1
优先权日:2022-12-24
标 题 :P450 Cytochrome Enzyme for Andrographolide Synthesis and Its Application
发明人：ZHOU JINGWEN; LI SHAN; GAO SONG; XU SHA; ZENG WEIZHU; YU SHIQIN
权利人:UNIV JIANGNAN
摘要:The present disclosure provides a P450 cytochrome enzyme for andrographolide synthesis and its application, belonging to the field of bioengineering. The present disclosure uses Saccharomyces cerevisiae CEN.PK2-1D as a host, and implements knockout of ROX1 and GAL80 genes on the genome, and integrative expression of GGPP synthase encoding gene and CPS diterpene synthase encoding gene at ROX1 site; and implements free expression of ApCPR and CYP71A8 and CYP71D10 both with truncated signal peptides, successfully constructing recombinant S. cerevisiae , and achieving de novo synthesis of 3,15,19-Trihydroxy-8(17),13-ent-labdadiene-16-oic acid. Compared with the blank, a response value of a product peak reaches 1.9*106, and this strategy provides necessary reference for analyzing biosynthetic pathway of andrographolide and using metabolic engineering to synthesize andrographolide and related derivatives thereof.

专利号:US-5907058-A
优先权日:1998-07-29
标题:Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters
发明人：MOENS LUC
权利人:MIDWEST RESEARCH INST
摘要:A process of preparing an acid addition salt of delta-aminolevulinic acid comprising: n dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures thereof to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing said alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.

专利号:US-6583317-B1
优先权日:2000-10-18
标 题 :Synthesis of acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters
发明人：MOENS LUC
权利人:MIDWEST RESEARCH INST
摘要:A process of preparing an acid addition salt of delta-aminolevulinc acid comprising:a) dissolving a lower alkyl 5-bromolevulinate and hexamethylenetetramine in a solvent selected from the group consisting of water, ethyl acetate, chloroform, acetone, ethanol, tetrahydrofuran and acetonitrile, to form a quaternary ammonium salt of the lower alkyl 5-bromolevulinate; andb) hydrolyzing the quaternary ammonium salt with an inorganic acid to form an acid addition salt of delta-aminolevulinic acid.

专利号:US-2024285670-A1
优先权日:2021-06-11
标题 :Therapeutic treatment of tumors by blocking the heme synthesis-export axis
发明人：TOLOSANO EMANUELA; FIORITO VERONICA; PETRILLO SARA; CHIABRANDO DEBORAH; ALLOCCO ANNA LUCIA; BERTINO FRANCESCA
权利人:UNIV DEGLI STUDI DI TORINO
摘要:A blocker of heme synthesis-export axis as active agent for use in the treatment of a tumor in a subject, wherein the blocker of heme synthesis-export axis upmodulates oxidative metabolism of tumor cells by upregulating the tricarboxylic acid (TCA) cycle and the oxidative phosphorylation (OXPHOS).

专利号:US-10975400-B2
优先权日:2013-02-07
标 题:5-aminolevulinic acid high-yield bacterial strain, preparation method and use thereof
发明人：ZHENG PING; Chen jiuzhou; PU WEI; SUN JIBIN; WU XINYANG; MA YANHE
权利人:TIANJIN INST IND BIOTECHNOLOGY CAS
摘要:A method for constructing an ALA production bacterial strain, the method enhances the activity of related enzymes promoting the synthesis of oxaloacetate and in the 5-aminolevulinic acid (ALA) production bacterial strain, or introducing exogenous related enzymes promoting the synthesis of oxaloacetate, such as phosphoenolpyruvate carboxylase or pyruvate carboxylase, and/or reducing the activity of related enzymes in the downstream metabolic pathway of succinyl coenzyme A in the bacterial strain, such as succinyl coenzyme A synthetase or succinate dehydrogenase, and/or reducing the activity of phosphoenolpyruvate carboxylated kinase and/or malic enzyme. An ALA high-yield bacterial strain constructed by utilizing the method, and method for utilizing the bacterial strain to prepare ALA.

专利号:US-7319164-B2
优先权日:2001-01-08
标 题:5-azido-laevulinic acid, method for the production thereof and its use
发明人：ALDENKORTT SVEN
权利人:ALDENKORTT SVEN
摘要:The present invention relates to 5-azido levulinic acid, a process for its preparation, its use. Using 5-azido levulinic acid as starting material for the synthesis of 5-amino levulinic acid hydrochloride it is possible to obtain the latter in good yield an in pharmaceutical acceptable quality. 5-Azido levuliniv acid is synthesized in that methyl 5-bromo levulinate and/or methyl 5-chloro levulinate is converted with aqueous hydrochloric acid and as a result of an incomplete bromine/chlorine exchange at the C-5-postion a mixture of 5-chloro levulinic acid and 5-bromo levulinic acid is obtained, and the obtained 5-chloro levulinic acid, a mixture of 5-chloro levulinic acid and 5-bromo levulinic acid and the pure 5-bromo levulinic acid is transferred into 5-azido levulinic acid by conversion with a nucleophilic azide.