CAS: 57044-25-4; (R)-Oxiran-2-Ylmethanol

上下游产品

CAS号107-18-6 烯丙醇 | CAS号14437-88-8 (R)-1-溴-2,3-二羟基丙烷 | CAS号556-52-5 缩水甘油 | CAS号96-24-2 3-氯-1,2-丙二醇 | CAS号2461-40-7 丁酸缩水甘油酯 | CAS号41274-09-3 (R)-对甲苯磺酸-1-甘油酯 | CAS号57090-45-6 (R)-(-)-3-氯-1,2-丙二醇 | CAS号110207-31-3 oxiran-2-ylmeth... | CAS号106-91-2 甲基丙烯酸缩水甘油酯 | CAS号24553-03-5 phenylacetate o... | CAS号14437-88-8 (R)-1-溴-2,3-二羟基丙烷 | CAS号184488-19-5 (S)-2-((2-氟苯氧基)... | CAS号185140-87-8 [(2S)-oxiran-2-... | CAS号256372-58-4 (S)-2-((4-(三氟甲基... | CAS号181140-34-1 (R)-N-环氧丙基邻苯二甲酰亚胺 | CAS号64491-68-5 (S)-缩水甘油基甲醚 | CAS号60299-43-6 1-脱氧-D-木酮糖 | CAS号65031-96-1 (S)-丁酸缩水甘油酯 | CAS号6425-32-7 3-吗啉基-1,2-丙二醇 | CAS号598-44-7 propanediol

烯丙醇置于氧气体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,50.0 °C,101.33 Kpa 条件下,反应 24.0H,以12%的收率获得产物(R)-缩水甘油
参考文献:在二甲基甲酰胺介质中分子氧在含 钴(II)介孔二氧化硅上催化烯烃环氧化†
标题:在二甲基甲酰胺介质中分子氧在含 钴(II)介孔二氧化硅上催化烯烃环氧化†
摘要:钴(II)席夫碱配合物已被固定在si-mcm-41的表面上,以制备新的催化剂.含胺基的有机部分3-氨基丙基-三乙氧基硅烷首先通过硅醇盐途径固定在si-Mcm-41的表面上.与水杨醛缩合后,胺基在中孔基质中提供双齿席夫碱部分,随后将其用于锚定钴(II)中心.通过紫外可见光谱,红外(ir),Epr光谱和小角x射线衍射(xrd)分析以及n 2表征了制备的催化剂.吸附研究.在大气压力下,在不存在其他牺牲还原剂的情况下,在二甲基甲酰胺介质中,烯烃分子(包括苯乙烯和烯丙醇)与分子氧的环氧化反应中测试了催化活性.反应似乎是通过自由基形成机理进行的.固定化的催化剂在烯烃环氧化中显示出非常好的活性和环氧化物选择性.值得注意的是,催化剂可以被回收和再利用而没有任何活性的损失.
DOI:10.1039/c4Cy00084F

专利信息

专利号:US-5541347-A
优先权日:1993-12-07
标 题 :Synthesis of bisindolylmaleimides
发明人：FAUL MARGARET M; JIROUSEK MICHAEL R; WINNEROSKI II LEONARD L
权利人:LILLY CO ELI
摘要:The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.

专利号:US-6239313-B1
优先权日:2000-02-16
标 题 :Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides
发明人：KAKULAPATI RAMA RAO; NANDURI BHANUMATHI; ELETI RAJENDER REDDY
权利人:COUNCIL SCIENT IND RES
摘要:The invention relates to a process for the solid state synthesis of enantiopure β-aminoalcohols by preparing inclusion complexes of aryloxyepoxide with cyclodextrin by adding an epoxide in equimolar ratio in an organic solvent to an aqueous solution of cyclodextrin, reacting the cyclodextrin complex of aryloxyepoxide with a nucleophile in solid state by intimately grinding the mixture using a mortar and pestle, continuing the mixing till the starting epoxide disappeared on tic, removing excess amines under vacuum, extracting the β-aminoalcohols produced with a solvent with yields of more than 50% and enantioselectivity of upto 100%.

专利号:US-5591852-A
优先权日:1990-08-10
标题 :Process for the preparation of nucleotides
发明人：VEMISHETTI PURUSHOTHAM; BRODFUEHRER PAUL R; HOWELL HENRY G; SAPINO JR CHESTER
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.

专利号:US-5714597-A
优先权日:1994-07-07
标题:Use of carbocation scavenger during oligonucleotide synthesis
发明人：RAVIKUMAR VASULINGA; ANDRADE MARK; MULVEY DENNIS; COLE DOUGLAS L
权利人:ISIS PHARMACEUTICALS INC
摘要:During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.

专利号:US-2005043376-A1
优先权日:1996-12-03
标题:Synthesis of epothilones, intermediates thereto, analogues and uses thereof
发明人：DANISHEFSKY SAMUEL J; BERTINATO PETER; SU DAI-SHI; MENG DONGFANG; CHOU TING-CHAO; KAMENECKA TED; SORENSEN ERIK J; BALOG AARON; SAVIN KENNETH A
摘要:The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

专利号:US-8431714-B2
优先权日:2007-04-16
标题:Synthesis of drug conjugates via reaction with epoxide-containing linkers
发明人：MCKENNA CHARLES E; KASHEMIROV BORIS A; BALA JOY LYNN F
权利人:MCKENNA CHARLES E; KASHEMIROV BORIS A; BALA JOY LYNN F; UNIV SOUTHERN CALIFORNIA
摘要:The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases.