CAS: 776-53-4; Ethyl 4-Amino-2-(Methylthio)Pyrimidin-5-Carboxylate

相似化合物

100973-67-9 771-81-3 588-36-3

上下游产品

ethyl 4-amino-2-thioxo-1H-pyrimidine-5-carboxylate dimethyl sulfate isothiosemicarbazonebenzaldehyde 3-methyl-4-2-cyano-2-(ethoxycarbonyl)vinylisothiosemicarbazone (4-amino-2-(methylthio)pyrimidin-5-yl)methanol 4-amino-2-(methylthio)pyrimidine-5-carboxylic acid 4-[4-(8-isopropyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]piperazine-1-carboxylic acid tert-butyl ester 4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

Ethyl (E)-2-Cyano-3-(S-Methylisothioureido)-2-Propenoate 以 溶剂黄146 作为反应溶剂,化学反应 1.0H,以71%的收率获得产物2-甲基巯基-4-氨基嘧啶-5-甲酸乙酯
参考文献:关于(e)-2-氰基-3-(s-甲基异硫脲基)-2-丙酸酯的分子内环化
标题:关于(e)-2-氰基-3-(s-甲基异硫脲基)-2-丙酸酯的分子内环化
摘要:
DOI:10.1007/s10593-010-0517-Y

专利信息

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

专利号:IL-180256-A
优先权日:2004-07-15
标题 :Pyrido [d – 2,3] pyrimidinyl-amine history, intermediates for synthesis, process for preparation of compounds, drug, pharmaceutical preparation, and use of history for drug preparation