CAS: 90-52-8; 8-Amino-6-Methoxyquinoline

• 英文名称8-Amino-6-Methoxyquinoline
• 中文名称6-甲氧基-8-氨基喹啉
• IUPAC名称6-methoxyquinolin-8-amine
• 其它别名6-甲氧基-8胺基喹啉; 6-Methoxyquinolin-8-Ylamine
• CAS编号90-52-8
• MFCD编号:MFCD00672902
• EINECS号:202-001-3
• FDA UNII编号:35HXP99PXF
• 分子式:C10H10N2O
• 分子量:174.2
• 产品CID: 1938420
• 产品分类有机原料→分子砌块→芳杂环类化合物→喹啉类化合物

• 相似结构搜索
• 产品信息参考;;
• InChIKey: YGGTVPCTAKYCSQ-UHFFFAOYSA-N
• InChI=1S/C10H10N2O/c1-13-8-5-7-3-2-4-12-10(7)9(11)6-8/h2-6H,11H2,1H3…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

相似化合物

物理性质

• 熔点41°C
• 沸点361.8±27.0°C at 760 mmHg
• 闪点361.8 °C at 760 mmHg
• 密度1.217±0.06 g/cm3(预测)
• pKa:3.49±0.10(预测)
• PSA:48.14
• LogP:1.8256
• 溶解性DMSO (Slightly), Methanol (Slightly)
• 外观形态棕色至极深棕色固体
• 储存条件在惰性气体(氮气或氩气)下 2–8 °C
• 产品应用该化合物是合成抗疟药物的中间体,如原金磷酸盐,马马奎因和五氯硝酸.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2A
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险等级IRRITANT
• 危险品标志Xi
• 安全声明S26,S37/39
• 危险类别码R36/37/38

欧盟法规

上下游产品

合成工艺路线路线简述

• 85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; 4 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,Neutralized,Rt
  标题:Primacenes: Novel Non-Cytotoxic Primaquine-Ferrocene Conjugates With Anti-Pneumocystis Carinii Activity
  作者:Matos,Joana; Vale,Nuno; Collins,Margaret S.; Gut,Jiri; Rosenthal,Philip J.; Et Al
  参考文献:Medchemcomm 日期:2010 卷标:1(3) 页码:199-201]
  
  63457-03-4 = 90-52-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 1 H,25 °C
  标题:Synthesis And Biological Evaluation Of Benzhydryl-Based Antiplasmodial Agents Possessing Plasmodium Falciparum Chloroquine Resistance Transporter (Pfcrt) Inhibitory Activity
  作者:Relitti,Nicola; Federico,Stefano; Pozzetti,Luca; Butini,Stefania; Lamponi,Stefania; Et Al
  参考文献:European Journal Of Medicinal Chemistry 日期:2021 卷标:215]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Carbon,Hydrazine Hydrate (1:1) Catalysts: Iron Chloride (Fecl3) Solvents: Methanol; 12 H,80 °C
  标题:Uncatalyzed,On Water Oxygenative Cleavage Of Inert C-N Bond With Concomitant 8,7-Amino Shift In 8-Aminoquinoline Derivatives
  作者:Botla,Vinayak; Pilli,Navyasree; Malapaka,Chandrasekharam
  参考文献:Green Chemistry 日期:2019 卷标:21(7) 页码:1735-1742]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Stannous Chloride Solvents: Ethanol; 1 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Ethyl Acetate,Water; Ph 11,Rt
  标题:Systematic Ligand Variation To Modulate The Electrochemical Properties Of Iron And Manganese Complexes
  作者:Rohner,Stefan S.; Kinzel,Niklas W.; Werle,Christophe; Leitner,Walter
  参考文献:Dalton Transactions 日期:2019 卷标:48(35) 页码:13205-13211]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol,Dichloromethane; 48 H,Rt
  标题:Influence Of Functionalized Substituents On The Electron-Transfer Abilities Of Copper Guanidinoquinoline Complexes
  作者:Stanek,Julia; Konrad,Marc; Mannsperger,Johannes; Hoffmann,Alexander; Herres-Pawlis,Sonja
  参考文献:European Journal Of Inorganic Chemistry 日期:2018 卷标:2018(46) 页码:4997-5006]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol; 45 Min,45 Psi,Rt
  标题:Ring-Substituted Quinolines As Potential Anti-Tuberculosis Agents
  作者:Vangapandu,Suryanarayana; Jain,Meenakshi; Jain,Rahul; Kaur,Sukhraj; Singh,Prati Pal
  参考文献:Bioorganic & Medicinal Chemistry 日期:2004 卷标:12(10) 页码:2501-2508]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Rt; 24 H,Rt
  标题:Novel Squaramides With In Vitro Liver Stage Antiplasmodial Activity
  作者:Ribeiro,Carlos J. A.; Espadinha,Margarida; Machado,Marta; Gut,Jiri; Goncalves,Lidia M.; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2016 卷标:24(8) 页码:1786-1792]
  
  = 90-52-8
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol
  标题:Transition Metal Free Oxygenation Of 8-Aminoquinoline Amides In Water
  作者:Yao,Xinghui; Weng,Xin; Wang,Kaixuan; Xiang,Haifeng; Zhou,Xiangge
  参考文献:Green Chemistry 日期:2018 卷标:20(11) 页码:2472-2476]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Solvents: Water
  标题:Reduction Of Heteroaromatic Nitro Compounds With Baker'S Yeast
  作者:Takeshita,Mitsuhiro; Yoshida,Sachiko
  参考文献:Heterocycles 日期:1990 卷标:31(12) 页码:2201-4]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: L-Ascorbic Acid Catalysts: Tris(2,2′-Bipyridyl)Ruthenium(Ii) Chloride Solvents: Methanol,Water; 5 H,Rt1.2 Reagents: Triethylamine; Rt
  标题:Visible-Light-Photocatalyzed Reductions Of N-Heterocyclic Nitroaryls To Anilines Utilizing Ascorbic Acid Reductant
  作者:Todorov,Aleksandar R.; Aikonen,Santeri; Muuronen,Mikko; Helaja,Juho
  参考文献:Organic Letters 日期:2019 卷标:21(10) 页码:3764-3768]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Carbon,Hydrazine Hydrate (1:1) Catalysts: Iron Chloride (Fecl3) Solvents: Methanol; 12 H,80 °C
  标题:Visible Light-Promoted Photocatalytic C-5 Carboxylation Of 8-Aminoquinoline Amides And Sulfonamides Via A Single Electron Transfer Pathway
  作者:Sen,Chiranjit; Sahoo,Tapan; Singh,Harshvardhan; Suresh,Eringathodi; Ghosh,Subhash Chandra
  参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(16) 页码:9869-9896]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Iron Chloride (Fecl3),Hydrazine Hydrate (1:1) Solvents: Methanol; 12 H,80 °C
  标题:5-Position-Selective C-H Trifluoromethylation Of 8-Aminoquinoline Derivatives
  作者:Kuninobu,Yoichiro; Nishi,Mitsumi; Kanai,Motomu
  参考文献:Organic & Biomolecular Chemistry 日期:2016 卷标:14(34) 页码:8092-8100]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium (Mof-74(Zn)-Supported),Titanium,Hexakis[μ-[1,4-Benzenedicarboxylato(2-)-Ko1:Ko′1]]Tetra-μ-Hydroxyocta-... Solvents: Water; 12 H,1 Atm,Rt
  标题:The Selective Hydrogenation Of Nitroarenes And Alkenes Catalyzed By Pd@mofs: The Role Of Electronic Interactions Between Pd Nanoparticles And Mofs On The Reaction
  作者:Xu,Jiaxian; Chen,Fei; Xu,Xuran; Lu,Guo-Ping
  参考文献:Molecular Catalysis 日期:2020 卷标:495]
  
  85-81-4 = 90-52-8
  反应条件:1.1 Reagents: Phenylsilane Catalysts: Dicobalt Octacarbonyl Solvents: Tetrahydrofuran; 3 H,100 °C
  标题:Cobalt Catalyzed Chemoselective Reduction Of Nitroarenes: Hydrosilylation Under Thermal And Photochemical Reaction Conditions
  作者:Panda,Surajit; Nanda,Amareshwar; Behera,Rakesh R.; Ghosh,Rahul; Bagh,Bidraha
  参考文献:Chemical Communications (Cambridge 日期:2023 卷标:59(30) 页码:4527-4530]
  
  90-34-6 = 90-52-8
  反应条件:1.1 Reagents: Piperidine Catalysts: (Oc-6-14)-[[2,3-Butanedione 2,3-Di(Oximato-Kn)](1-)][2,3-Butanedione 2,3-Di(Oxim...,Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis[2-(2-Pyri... Solvents: Acetonitrile; Rt -> -78 °C; 72 H,-78 °C
  标题:Minimization Of Back-Electron Transfer Enables The Elusive Sp3 C-H Functionalization Of Secondary Anilines
  作者:Zhao,Huaibo; Leonori,Daniele
  参考文献:Angewandte Chemie 日期:2021 卷标:60(14) 页码:7669-7674

海关参考信息

• 2905110000-甲醇
  2933310010-吡啶
  2908199090-其他酚的卤化衍生物
  2908999090-其他酚的硝化衍生物
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管