CAS: 90965-06-3; Dimethyl (1-Diazo-2-Oxopropyl)Phosphonate

• 英文名称Dimethyl (1-Diazo-2-Oxopropyl)Phosphonate
• 中文名称(1-重氮-2-氧丙基)膦酸二甲酯
• IUPAC名称1-[dimethoxy(oxido)-λ5-phosphanylidene]-2-oxopropane-1-diazonium
• 其它别名(1-重氮-2-氧代丙基)膦酸二甲酯; Phosphonic Acid, P-(1-Diazo-2-Oxopropyl)-, Dimethyl Ester
• CAS编号90965-06-3
• MFCD编号:MFCD07368360
• EINECS号:692-521-0
• FDA UNII编号:96G79J0LR6
• 分子式:C5H9N2O4P
• 分子量:192.11
• 产品CID: 1943816
• 产品分类有机原料→分子砌块→脂肪链类化合物

• 相似结构搜索
• InChIKey: SQHSJJGGWYIFCD-UHFFFAOYSA-N
• InChI=1S/C5H9N2O4P/c1-4(8)5(7-6)12(9,10-2)11-3/h1-3H3…
• 计算化学: 氢键受体数4.0氢键供体数0.0可旋转键数4.0

相似化合物

物理性质

• 闪点2°C
• 密度1.28
• PSA:89.0
• LogP:0.6896
• 折射率n20/D1.352-1.354
• 溶解性Chloroform, Methanol (Slightly)
• 外观形态淡黄色至黄色油状物
• 储存条件2-8°C

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  易燃液体 类别3
  急性毒性 类别3(经口)
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H332 |吸入有害.
  H312 |皮肤接触有害.
  H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H226 |易燃液体和蒸气.
  H301 |吞咽会中毒.
• 防范说明P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P304+P340-P330-P370+P378-P501
• 危险等级3
• UN编号1648.0
• 危险品标志F,Xn
• 包装等级Ⅱ
• 安全声明16-26-36/37
• 危险类别码11-20/21/22-36
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Benzene,Tetrahydrofuran; 0 °C; 1 H,Rt1.2 Reagents: Tosyl Azide Solvents: Benzene; Overnight,Rt
  标题:Synthesis And Cytotoxicity Evaluation Of Aryl Triazolic Derivatives And Their Hydroxymethine Homologues Against B16 Melanoma Cell Line
  作者:Kalhor-Monfared,Shiva; Beauvineau,Claire; Scherman,Daniel; Girard,Christian
  参考文献:European Journal Of Medicinal Chemistry 日期:2016 卷标:122 页码:436-441]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene,Tetrahydrofuran; 10 Min,0 °C; 1 H,0 °C1.2 Reagents: 4-Acetamidobenzenesulfonyl Azide; 10 Min,0 °C; Overnight,Rt
  标题:Regioselective Synthesis Of 4-(2-Alkyl-5-Methyl-2H-Pyrazol-3-Yl)Piperidines
  作者:Dirat,Olivier; Clipson,Alex; Elliott,Jason M.; Garrett,Sasha; Brian Jones,A.; Et Al
  参考文献:Tetrahedron Letters 日期:2006 卷标:47(11) 页码:1729-1731]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Potassium Carbonate,Tosyl Azide Solvents: Acetonitrile; 2 H,Rt
  标题:(E) Enol Ethers From The Stereoselective Reduction Of α-Alkoxy-β-Ketophosphonates And Wittig Type Reaction
  作者:Dayoub,Wissam; Doutheau,Alain
  参考文献:Science China: Chemistry 日期:2010 卷标:53(9) 页码:1937-1945]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 1 H,0 °C1.2 Reagents: Tosyl Azide; 30 Min,0 °C
  标题:Asymmetric Synthesis And Chiroptical Properties Of Enantiopure Helical Ferrocenes
  作者:Urbano,Antonio; Del Hoyo,Ana M.; Martinez-Carrion,Alicia; Carreno,M. Carmen
  参考文献:Organic Letters 日期:2019 卷标:21(12) 页码:4623-4627]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Benzene,Tetrahydrofuran; 45 Min,0 - 5 °C1.2 Reagents: Tosyl Azide Solvents: Benzene; 2 H,5 °C -> Rt
  标题:Novel Formation And Use Of A Nicholas Carbocation In The Synthesis Of Highly Substituted Tetrahydrofurans
  作者:Christie,Steven D. R.; Davoile,Ryan J.; Elsegood,Mark R. J.; Fryatt,Ross; Jones,Raymond C. F.; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2004 卷标:(21) 页码:2474-2475]
  
  941-55-9 + 4202-14-6 = 90965-06-3
  反应条件:1.1 Solvents: Tetrahydrofuran; 1 H,0 °C1.2 10 Min,0 °C
  标题:Asymmetric Total Synthesis Of The Gastroprotective Microbial Agent Ai-77-B
  作者:Ghosh,Arun K.; Bischoff,Alexander; Cappiello,John
  参考文献:European Journal Of Organic Chemistry 日期:2003 卷标:(5) 页码:821-832]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Benzene,1,2-Dimethoxyethane; 0 °C; 90 Min,0 °C1.2 Reagents: Tosyl Azide Solvents: Toluene; 1 H,0 °C -> Rt
  标题:The New Chemical Reporter 6-Alkynyl-6-Deoxy-Glcnac Reveals O-Glcnac Modification Of The Apoptotic Caspases That Can Block The Cleavage/activation Of Caspase-8
  作者:Chuh,Kelly N.; Batt,Anna R.; Zaro,Balyn W.; Darabedian,Narek; Marotta,Nicholas P.; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2017 卷标:139(23) 页码:7872-7885]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene,Tetrahydrofuran; Rt; 1 H,Rt1.2 Reagents: 4-Acetamidobenzenesulfonyl Azide Solvents: Tetrahydrofuran; 0 °C; 24 H,Rt
  标题:One-Pot Synthesis Of 2,3-Difunctionalized Indoles Via Rh(Iii)-Catalyzed Carbenoid Insertion C-H Activation/cyclization
  作者:Lv,Honggui; Shi,Jingjing; Wu,Bo; Guo,Yujuan; Huang,Junjun; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2017 卷标:15(38) 页码:8054-8058]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Tosyl Azide,1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Acetonitrile; 0 °C; 0 °C -> Rt; 3 H,Rt
  标题:Rh(Iii)-Catalyzed Redox-Neutral Annulation Of Azo And Diazo Compounds: One-Step Access To Cinnolines
  作者:Sun,Peng; Wu,Youzhi; Huang,Yue; Wu,Xiaoming; Xu,Jinyi; Et Al
  参考文献:Organic Chemistry Frontiers 日期:2016 卷标:3(1) 页码:91-95]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene,Tetrahydrofuran; 1 H,0 °C1.2 Reagents: Tosyl Azide Solvents: Toluene; 16 H,25 °C
  标题:Tuning Excited-State Properties Of [2.2]Paracyclophane-Based Antennas To Ensure Efficient Sensitization Of Lanthanide Ions Or Singlet Oxygen Generation
  作者:Wu,Shiqi; Galan,Laura Abad; Roux,Margaux; Riobe,Francois; Le Guennic,Boris; Et Al
  参考文献:Inorganic Chemistry 日期:2021 卷标:60(21) 页码:16194-16203]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene,Tetrahydrofuran; 1 H,0 °C1.2 Reagents: Tosyl Azide Solvents: Toluene; 16 H,25 °C
  标题:Tuning The Excited State Properties Of [2.2]Paracyclophane-Based Antennas To Ensure Efficient Sensitization Of Lanthanide Ions Or Singlet Oxygen Generation
  作者:Wu,Shiqi; Galan,Laura Abad; Roux,Margaux; Riobe,Francois; Le Guennic,Boris; Et Al
  参考文献:Chemrxiv 日期:2021 卷标:1 页码:1-10]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Benzene,Tetrahydrofuran; 0 °C; 0 °C -> Rt; 1 H,Rt1.2 Reagents: Tosyl Azide Solvents: Benzene; Overnight,Rt
  标题:Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4 Receptor Affinity And Subtly Govern H4/h3 Subtype Selectivity
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  参考文献:Journal Of Medicinal Chemistry 日期:2011 卷标:54(6) 页码:1693-1703]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Benzene,Tetrahydrofuran; 1 H,0 °C1.2 Reagents: 4-Acetamidobenzenesulfonyl Azide; 0 °C -> Rt; 3 H,Rt
  标题:Modifications Of C-2 On The Pyrroloquinoline Template Aimed At The Development Of Potent Herpes Virus Antivirals With Improved Aqueous Solubility
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  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Benzene,Tetrahydrofuran; 1 H,0 °C1.2 Reagents: Tosyl Azide Solvents: Benzene; 2 H,Rt
  标题:Cyclic Peptide-Polymer Complexes And Their Self-Assembly
  作者:Belanger,Dominique; Tong,Xia; Soumare,Sadia; Dory,Yves L.; Zhao,Yue
  参考文献:Chemistry - A European Journal 日期:2009 卷标:15(17) 页码:4428-4436]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 1 H,0 °C
  标题:Synthesis Of Cationic [4],[5],And [6]Azahelicenes With Extended π-Conjugated Systems
  作者:Hruby,Samuel; Ulc,Jan; Cisarova,Ivana; Kotora,Martin
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  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Potassium Carbonate,Tosyl Azide Solvents: Acetonitrile; Rt -> 0 °C; 3 H,Rt
  标题:One-Pot Conversion Of Activated Alcohols Into 1,1-Dibromoalkenes And Terminal Alkynes Using Tandem Oxidation Processes With Manganese Dioxide
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  参考文献:Tetrahedron 日期:2006 卷标:62(28) 页码:6673-6680]
  
  4202-14-6 = 90965-06-3 [标题:Reaction Conditions
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  作者:Quesada,Ernesto; Taylor,Richard J. K.
  参考文献:Tetrahedron Letters 日期:2005 卷标:46(38) 页码:6473-6476]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Tosyl Azide,Sodium Hydride Solvents: Tetrahydrofuran
  标题:Exocyclic Stereocontrol Via Asymmetric Hydrovinylation In The General Synthesis Of Pseudopterogorgia Natural Products. Stereoselective X-Y-Mediated Cyclization Studies Of An Allene-Ynamide And An Allene-Aldehyde
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  参考文献:2008 卷标:69(1)]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene; 10 Min,0 °C1.2 Reagents: 4-Acetamidobenzenesulfonyl Azide Solvents: Tetrahydrofuran; 16 H,Rt
  标题:Design,Synthesis,And Evaluation Of Novel δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity In An Isoniazid-Resistant Mycobacterium Tuberculosis Mutant
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  参考文献:Journal Of Medicinal Chemistry 日期:2023 卷标:66(15) 页码:10289-10310]
  
  941-55-9 + 4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene,Tetrahydrofuran
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  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 1 H,0 °C1.2 Reagents: Tosyl Azide Solvents: Tetrahydrofuran; 10 Min,0 °C
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  参考文献:Advanced Synthesis & Catalysis 日期:2011 卷标:353(1) 页码:113-124]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Potassium Carbonate,4-Acetamidobenzenesulfonyl Azide Solvents: Acetonitrile; 0 °C; 16 H,0 °C
  标题:Enantiomer Stability Of Atropisomeric 1,5-Disubstituted 1,2,3-Triazoles
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  参考文献:Chemrxiv 日期:2021 卷标:1 页码:1-28]
  
  4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene; 1 H,0 °C1.2 Reagents: 4-Acetamidobenzenesulfonyl Azide Solvents: Tetrahydrofuran; 0 °C; 24 H,Rt
  标题:Organocatalytic Enantioselective 1,3-Dipolar Cycloadditions Between Seyferth-Gilbert Reagent And Isatylidene Malononitriles: Synthesis Of Chiral Spiro-Phosphonylpyrazoline-Oxindoles
  作者:Du,Taiping; Du,Fei; Ning,Yanqiang; Peng,Yungui
  参考文献:Organic Letters 日期:2015 卷标:17(5) 页码:1308-1311]
  
  941-55-9 + 4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran,Hexane
  标题:Tyrosine Kinases As Target For The Synthesis Of Anti-Andiogenic And Anti-Cancer Compounds
  作者:Colombo,Francesco
  参考文献:2010]
  
  941-55-9 + 4202-14-6 = 90965-06-3
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Benzene,Tetrahydrofuran; 0 °C; 0 °C -> Rt; 12 H,Rt
  标题:Unexpected Halogen Exchange With Halogenated Solvents In The Iron(Iii) Promoted Oxa-Alkyne And Aza-Alkyne Prins Cyclizations
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  参考文献:Arkivoc (Gainesville 日期:2007 卷标:(4) 页码:331-343

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