专利号:US-2020047146-A1 优先权日:2017-03-17 标 题 :Hydroxyalkylated polyacrylamide surface coatings for in situ synthesis of dna arrays 发明人:MCGALL GLENN 权利人:CENTRILLON TECH HOLDINGS CORPORATION 摘要:The present disclosure relates to processes for derivatizing a surface of a substrate with a covalently bonded thin film of hydroxalkylated poly(acrylamide) as a platform for the synthesis of a biomolecule array. These processes can also be used to prepare a surface of a substrate for an in situ solid-phase synthesis of biomolecule array.
专利号:US-9802890-B2 优先权日:2006-02-21 标 题 :Processes for the convergent synthesis of calicheamicin derivatives 发明人:MORAN JUSTIN KEITH; GU JIANXIN 权利人:WYETH LLC 摘要:This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
专利号:US-9856205-B2 优先权日:2011-09-28 标 题:Method for the selective production of N-methyl-para-anisidine 发明人:IVANOV YURIY ALEXANDROVICH; BELIAKOV NIKOLAY GRIGORIEVICH 权利人:IVANOV YURIY ALEXANDROVICH; FROLOV ALEXANDER YURIEVICH; BELIAKOV NIKOLAY GRIGORIEVICH; IFOTOP LLC 摘要:The invention “Method for selective synthesis of N-methyl-para-anisidineâ€? relates to chemical technology processes, namely to catalytic alkylation of aromatic amines and nitro compounds. n The invention relates to the method for synthesis of N-methyl-para-anisidine (N-methyl-para-methoxyaniline; N-methyl-para-amino anisole) from para-anisidine (para-amino anisole; para-methoxyaniline) or para-nitro anisole (1-methoxy-4-nitrobenzene) and methanol in the presence of hydrogen or without hydrogen on heterogeneous catalyst. n Proposed method permits to use existing process plants used for obtaining aniline and 14-methylaniline. n The invention purpose is to provide the possibility to produce N-methyl-para-anisidine with purity at least 98% and high output that allows arrangement of highly profitable industry-scale manufacturing process.
专利号:US-7737089-B2 优先权日:2002-12-23 标题:Photoactivatable two-stage protective groups for the synthesis of biopolymers 发明人:GUEIMIL RAMON; SCHEFFLER MATTHIAS; BEIJER BARBRO 权利人:FEBIT HOLDING GMBH 摘要:The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.
专利号:US-7253324-B1 优先权日:2007-01-23 标 题:Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers 发明人:MAJEED MUHAMMED; THOMAS SAMUEL MANOHARAN; NAGABHUSHANAM KALYANAM; BALAKRISHNAN SIVAPRAKASH KURUM; PRAKASH SUBBALAKSHMI 权利人:SAMI LABS LTD 摘要:Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.
专利号:US-8637434-B2 优先权日:1996-04-17 标题 :System for photolithographic synthesis of polymer arrays 发明人:GOLDBERG MARTIN J; DIGGELMAN MARTIN; HUBBELL EARL A; MCGALL GLENN H; NAM NGO; MORRIS MACDONALD S; YAMAMOTO MELVIN; TAN JENNIFER; RAVA RICHARD 权利人:AFFYMETRIX INC 摘要:The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 71. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 162. 摘要:Li, G.; Szostak, M., Science of Synthesis Knowledge Updates, (2020) 2, 224. 摘要:Li, G.; Szostak, M., Science of Synthesis Knowledge Updates, (2020) 2, 231. 摘要:Dekeukeleire, S.; D'hooghe, M.; De Kimpe, N., Science of Synthesis Knowledge Updates, (2011) 3, 133.