CAS: 107264-09-5; 1-Fluoropyridin-1-Ium Tetrafluoroborate

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参考文献:Umemoto,Teruo;Harasawa,Kikuko;Tomizawa,Ginjiro;Kawada,Kosuke;Tomita,+,Bull. Chem. Soc. Jap.,64,(1991) N,C. 1081-1092
标题:Umemoto,Teruo;Harasawa,Kikuko;Tomizawa,Ginjiro;Kawada,Kosuke;Tomita,+,Bull. Chem. Soc. Jap.,64,(1991) N,C. 1081-1092

专利信息

专利号:US-2023287032-A1
优先权日:2020-08-14
标 题:Synthesis of fluorinated nucleotides
发明人：CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO
权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:US-2024239924-A1
优先权日:2021-04-30
标题:Synthesis of sulfonyl halide terminated polyethylene
发明人：BROONER RACHEL E M; SENECAL TODD D; KEAN ZACHARY S
权利人:DOW GLOBAL TECHNOLOGIES LLC
摘要:Methods for preparing end-functionalized polyolefin, The methods include polymerizing one or more olefin monomers in the presence of an aluminum chain transfer agent to produce a polymeryl aluminum species; treating the polymeryl aluminum species with sulfur oxide compound at a reactor temperature to form a polymeryl sulfinate; and oxidizing the polymeryl sulfinate; wherein the end-functionalized polyolefin comprises a polymer backbone having at least 30 carbon atoms; and the end-functionalized polyolefin comprises a sulfur containing group,

专利号:EP-1422235-B1
优先权日:2001-07-26
标题 :Stereoselective method of producing 6alpha-fluoropregnanes and intermediaries
发明人：MURILLO GARRIDO JOSE VICENTE; SILVA GUISASOLA LUIS OCTAVIO; MARTIN JUAREZ JORGE
权利人:RAGACTIVES SL
摘要:6 alpha -fluorpregnanes (I), where the dotted line between positions 1 and 2 represents a single or double bond; R1 is OH, OCOR2, X, SO3R3, or an (R7)(R8)(R9)SiO- group, where X is halogen, R2 and R3 are C1-6 alkyl or phenyl optionally substituted by C1-4 alkyl, and R7, R8 and R9, equal or different, are C1-6 alkyl or phenyl optionally substituted by C1-4 alkyl, can be obtained by means of a high stereoselectivity process comprising reacting a 3-(trisubstituted)silyloxy-pregna-3,5-diene (IV) with a fluorinating agent selected among N-fluorosulfonimides and N-fluorosulfonamides. The 6 alpha -fluorpregnanes (I) are intermediates for the synthesis of steroids useful as anti-inflammatory and anti-asthmatic agents.

专利号:WO-2022035917-A1
优先权日:2020-08-14
标题:Synthesis of fluorinated nucleotides

专利号:WO-2022232500-A1
优先权日:2021-04-30
标题:Synthesis of sulfonyl halide terminated polyethylene