CAS: 137348-86-8; Di-Tert-Butyl Diisopropylphosphoramidite

相似化合物

117924-33-1 916996-01-5 137348-88-0

上下游产品

CAS号921-26-6 二氯-N,N-二异丙基亚磷酰胺 | CAS号75-65-0 叔丁醇 | CAS号137348-88-0 叔丁基四异丙基磷酸二阿米迪特 | CAS号108-18-9 二异丙胺 | CAS号145545-15-9 [3,4-ditert-but...

二异丙胺置于三乙胺,三氯化磷体系中,用 乙醚 用作溶剂,化学反应 3.0H,反应生成N,N-二异丙基亚磷酰胺二叔丁酯
参考文献:亚磷酰胺作为o-磷酸化剂及其反应性的研究
标题:亚磷酰胺作为o-磷酸化剂及其反应性的研究
摘要:摘要 O-磷酸化肽和氨基酸在生命系统中很重要.本文采用两种方法合成了二烷基-N,N-二烷基亚磷酰胺(Ddpa) 3 .在四唑的存在下,Ddpa与相应氨基酸的羟基反应,然后氧化,以非常好的收率获得o-磷酰基氨基酸甲酯.还介绍了 Ddpa 反应性的系统研究.
Doi:10.1080/10426500008045253

专利信息

专利号:US-7557096-B2
优先权日:1998-01-09
标题 :Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
发明人：PETTIT GEORGE R; RHODES MONTE R
权利人:UNIV ARIZONA
摘要:Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugsâ€?.

专利号:US-2005266068-A1
优先权日:2002-05-24
标题 :Cardiolipin molecules and methods of synthesis
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; AHMAD IMRAN
权利人:NEOPHARM INC
摘要:The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation, particularly a short-chain cardiolipin. The methods comprise reacting a 1,2-O-sn-diacyl/1,2-O-sn-dialkyl glycerol or a 2-O-protected glycerol, with a phosphoramidite reagent or a phosphate triester to produce a protected cardiolipin, which is deprotected to prepare the short chain cardiolipin. The reaction schemes can be used to generate new variants of cardiolipin. The cardiolipin prepared by the present methods can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes can also include ligands for targeting a particular cell type or specific tissue.

专利号:US-7279466-B2
优先权日:1998-01-09
标题:Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

专利号:US-2007073077-A1
优先权日:1998-01-09
标题:Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

专利号:US-2008146528-A1
优先权日:1998-01-09
标 题:Synthesis of combretastatin a-4 prodrugs and trans-isomers thereof

专利号:WO-2022123501-A1
优先权日:2020-12-10
标题:Protected deoxydidehydro-nucleosides
发明人：SHRESTHA RINU; HARRIS LAWRENCE DANIEL; WOOD JAMES MICHAEL
权利人:VICTORIA LINK LTD
摘要:The invention provides compounds of the Formula (I) or the Formula (Ia) which are useful intermediates in the synthesis of potential antiviral drugs such as 3'-deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP).