专利号:WO-2022256490-A9 优先权日:2021-06-03 标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus 发明人:LOCKWOOD MARK 权利人:ANTIOS THERAPEUTICS INC 摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.
专利号:US-9994526-B2 优先权日:2011-04-04 标 题 :Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate 发明人:STIVANELLO MARIANO; HUBER FLORIAN ANTON MARTIN; RICCI ANTONIO 权利人:LUNDBECK PHARMACEUTICALS ITALY S P A 摘要:Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.
专利号:US-10011567-B1 优先权日:2017-03-09 标题 :Method for the synthesis of acrylate derivatives 发明人:WANG MINGWEN; ZHANG YUE 权利人:INNOSCI LLC 摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.
专利号:US-9724673-B2 优先权日:2011-06-30 标 题:Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles 发明人:LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE 权利人:LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE; UNIV NANTES; CENTRE NAT RECH SCIENT 摘要:A supported alkoxylated organotin reactant, to the process for preparing same, to the use of such a reactant as a catalyst for heterogeneous-phase organic synthesis, and also to a process for heterogeneous-phase synthesis of 5-substituted or 1,5-disubstituted tetrazoles using such a reactant.
专利号:US-2023286893-A1 优先权日:2022-03-09 标题 :Vanillylidenechloroacetone and its use thereof in synthesis of calebin-a 发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; PENTAKOTA PARADESI NAIDU 权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; PENTAKOTA PARADESI NAIDU 摘要:The present invention discloses a compound, Vanillylidenechloroacetone (VCA)—1-Chloro-4-(4′-hydroxy-3′-methoxy-phenyl)-but-3-en-2-one, and the process of preparing the same. The invention also discloses a process for synthesis of Calebin-A from Vanillylidenechloroacetone.
专利号:US-7179919-B2 优先权日:2004-03-18 标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 发明人:SONG JINHUA J; TAN ZHULIN; YEE NATHAN K; SENANAYAKE CHRIS HUGH; XU JINGHUA; GALLOU FABRICE 权利人:BOEHRINGER INGELHEIM PHARMA 摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.
参考文献:10.2166/wh.2009.156 摘要:Muhammad N, Sinha R, Krishnan R, Patterson CL, Haught RC, Harms HH, Seville R. Evaluating a composite cartridge for small system drinking water treatment. J Water Health. 2010 Jun;8(2):212–23. doi: 10.2166/wh.2009.156.