CAS: 218301-22-5; 2-Fluoro-5-Formylbenzonitrile

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CAS号920-39-8 异丙基溴化镁 | CAS号179897-89-3 5-溴-2-氟苯腈 | CAS号218301-21-4 2-fluoro-5-bis-... | CAS号180302-35-6 2-氟-5-(溴甲基)苯腈 | CAS号544-92-3 氰化亚铜 | CAS号77771-02-9 3-溴-4-氟苯甲醛 | CAS号550363-85-4 2-氟-5-甲酰基苯甲酸 | CAS号180302-35-6 2-氟-5-(溴甲基)苯腈 | CAS号218301-30-5 2-fluoro-5-(hyd... | CAS号22782-40-7 2-Amino-5-formy... | CAS号288309-07-9 2-氟-5-乙酰基苯甲腈 | CAS号227609-85-0 2-氟-5-甲醇苯甲腈 | CAS号763114-25-6 2-氟-5-[(3-氧代-1(... | CAS号763114-26-7 5-[(3,4-二氢-4-氧代... | CAS号676602-31-6 3-氰基-4-氟苯甲酸甲酯 | CAS号1176161-37-7 5-(Diethoxymeth...

5-(1,3-Dioxolan-2-yl)-2-Fluorobenzonitrile置于iron(III) Chloride Hexahydrate,乙醛体系中,用 二氯甲烷 用作溶剂,化学反应 0.25H,以95%的收率获得2-氟-5-甲酰基苯腈
参考文献:Fecl 3 .6H 2 O /乙醛,一种通过反缩醛化工艺 对缩酮和缩醛进行脱保护的通用系统
标题:Fecl 3 .6H 2 O /乙醛,一种通过反缩醛化工艺 对缩酮和缩醛进行脱保护的通用系统
摘要:本文描述了由fecl 3 .6H 2 O /乙醛介导的对缩酮/缩醛的轻度和有效催化脱保护.铁(III)/醛系统的多功能性和高化学选择性通过大量实例证明.在硅胶垫上过滤,然后蒸发掉挥发性副产物后,几乎定量分离了脱保护的酮/醛.
Doi:10.1039/c6Nj03439J

专利信息

专利号:US-10874667-B2
优先权日:2016-10-14
标题 :Pharmaceutical salt of antitumor heterocyclic imidazole compound
发明人：FAN XING; LI WENHUA; QIN JIHONG
权利人:SHANGHAI HUILUN LIFE SCIENCE & TECH CO LTD; SHANGHAI HUILIN LIFE SCINECE & TECH CO LTD
摘要:The present invention relates to the field of pharmaceutical synthesis, and in particular to an antitumor heterocyclic imidazole compound (I), namely: a pharmaceutical salt of 4-(3-(4-(1H-imidazo[4,5-b]pyridine-5-yl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(dihydro)-ketone, a preparation method therefor, a pharmaceutical composition thereof and a use thereof in the preparation of antitumor drugs. The pharmaceutical salt of the compound (I) in the present invention may be used in the preparation of a medicament for the treatment or prevention of conditions which can be improved by inhibiting PARP activity.

专利号:US-8507538-B2
优先权日:2009-11-13
标 题:Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9481659-B2
优先权日:2011-05-13
标 题 :Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; CELGENE INT II SÀRL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:WO-2015088564-A1
优先权日:2013-12-13
标 题:P2x4 receptor modulating compounds
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.