CAS: 2203-97-6; 4-(2-((8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-Dimethyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)-2-Oxoethoxy)-4-Oxobutanoic Acid

上下游产品

CAS号108-30-5 丁二酸酐 | CAS号50-23-7 氢化可的松 | CAS号50-23-7 氢化可的松

丁二酸酐,氢化可的松置于吡啶体系中,化学反应 5.0H,以94%的收率获得氢化可的松琥珀酸酯
参考文献:具有有效的抗炎活性和提高的安全性的基于呋喃喃的一氧化氮释放型糖皮质激素衍生物的设计与合成.
标题:具有有效的抗炎活性和提高的安全性的基于呋喃喃的一氧化氮释放型糖皮质激素衍生物的设计与合成.
摘要:合成了一系列基于呋喃烷的一氧化氮释放糖皮质激素衍生物.药理分析表明,包括i(4),I(5)和i(6)在内的三种化合物具有抗炎活性.此外,与主要化合物氢化可的松相比,I(6)的安全性大大提高.由于体内释放no,可有效避免糖皮质激素的副作用,包括高血压和骨质疏松症.
Doi:10.1016/j.Bmcl.2006.11.018

专利信息

专利号:WO-2017179021-A1
优先权日:2016-04-15
标题 :A new method for the reprogramming of cells
发明人：ELVASSORE NICOLA; LUNI CAMILLA; GIULITTI STEFANO; GAGLIANO ONELIA; SERENA ELENA; ZAMBON ALESSANDRO
权利人:USTEM S R L
摘要:A method of reprogramming adult cells to iPSC is disclosed. The method comprises seeding adult cells in a microfluidic cell culture chamber; submitting the seeded cells to reprogramming by delivering into said cells suitable reprogramming factors and/or inducing into said cells the synthesis of suitable reprogramming factors, with suitable vectors and culturing said cells until iPSC are obtained. The height of the culture medium comprising said suitable reprogramming factors and/or vectors in the microfluidic cell culture chamber with respect to the bottom of the chamber is in the range from 500 to 50 µm. A microfluidic system configured to perform cell reprogramming is further disclosed.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-5405772-A
优先权日:1993-06-18
标题 :Medium for long-term proliferation and development of cells
发明人：PONTING IAN L O
权利人:AMGEN INC
摘要:A serum-free or serum-depleted medium for the short- and long-term proliferation and development of cells, particularly hematopoietic cells and bone marrow stromal cells, the medium comprising cell proliferation and development effective amounts of: a standard culture medium such as Iscove's modified Dulbecco's medium; serum albumin; transferrin; a source of lipids and fatty acids; cholesterol; a reducing agent; pyruvate; a glucocorticoid (when the cells to be cultured are hematopoietic cells); nucleosides for synthesis of DNA and RNA; growth factors that stimulate the proliferation and development of stromal cells and cells from a variety of tissues or organs, such as epidermal growth factor, fibroblast growth factor, platelet derived growth factor, and insulin; and extracellular matrix materials, such as collagen, fibronectin, and laminin.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:WO-2022246227-A1
优先权日:2021-05-20
标 题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms