2-羟基-4-甲基苯甲醛 以 Neat (No Solvent) 用作溶剂,化学反应生成2-叔丁基-6-甲基苯酚 参考文献:Nesterova; Verevkin; Malova,Journal Of Applied Chemistry Of The Ussr,1985,Vol. 58,# 4 Pt 1,P. 748-754 标题:Nesterova; Verevkin; Malova,Journal Of Applied Chemistry Of The Ussr,1985,Vol. 58,# 4 Pt 1,P. 748-754
专利号:US-10053406-B2 优先权日:2015-10-23 标题 :Synthesis of honokiol 发明人:JARACZ STANISLAV; KOZLOWSKI MARISA; EUN LEE YOUNG; KIM SUN MIN 权利人:COLGATE PALMOLIVE CO; UNIV PENNSYLVANIA 摘要:Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-3979460-A 优先权日:1974-07-01 标 题 :Process for the preparation of an organomercaptophenol from sulfur, a 2,6-disubstituted phenol, and an activated olefin or an epoxy compound 发明人:HAY ALLAN S 权利人:GEN ELECTRIC 摘要:A process for the preparation of an organomercaptophenol is described which comprises the reaction of sulfur with a 2,6-disubstituted phenol carried out in the presence of (1) a base, (2) an activated olefin or an epoxy compound, (3) and a solvent with a high dielectric constant. The organomercaptophenols produced by this process are useful as monomers in the synthesis of esters, carbonates, ethers, epoxy compounds, among many other chemicals synthesized from monohydric phenols. In addition, the oganomercaptophenols are also useful as antioxidants.
专利号:US-4064158-A 优先权日:1974-07-01 标题:Process for the preparation of an organomercaptophenol from sulfur, a 2,6-disubstituted phenol, and an activated olefin or an epoxy compound 发明人:HAY ALLAN S 权利人:GEN ELECTRIC 摘要:A process for the preparation of an organomercaptophenol is described which comprises the reaction of sulfur with a 2,6-disubstituted phenol carried out in the presence of (1) a base, (2) an activated olefin or an epoxy compound, (3) and a solvent with a high dielectric constant. The organomercaptophenols produced by this process are useful as monomers in the synthesis of esters, carbonates, ethers, epoxy compounds, among many other chemicals synthesized from monohydric phenols. In addition, the organomercaptophenols are also useful as antioxidants.
专利号:US-9957461-B2 优先权日:2016-07-14 标题:Polyester dispersants, synthesis and use thereof 发明人:RUHE JR WILLIAM RAYMOND 权利人:CHEVRON ORONITE CO; CHEVRON USA INC 摘要:A polyester composition, suitable for use as a dispersant in lubricating oils, is disclosed. The polyester composition is prepared by reacting (a) an acylating agent selected from an aliphatic-substituted succinic acylating agent, an aromatic polycarboxylic acylating agent, and combinations thereof; and (b) a hydroxyalkyl-substituted tertiary amine compound of the following structure: n nwherein R′ is a C 1-24 aliphatic group; R in each of the x (RO), y (RO) and z (RO) groups is independently C 2-4 alkylene; x+y is in a range of 2 to 7; and z is in a range of 1 to 5.
专利号:EP-3364957-B1 优先权日:2015-10-23 标 题:Improved synthesis of honokiol
[参考文献]: Cynthia D Selassie, Et Al. Cellular Apoptosis And Cytotoxicity Of Phenolic Compounds: A Quantitative Structure-Activity Relationship Study. J Med Chem. 2005 Nov 17;48(23):7234-42.
合成参考文献
摘要:Wong, Y.-S., Science of Synthesis, (2009) 46, 599. 摘要:Wong, Y.-S., Science of Synthesis, (2009) 46, 609. 摘要:Ronson, T. O.; Fairlamb, I. J. S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 183. 摘要:P. Demerseman, J. P. Lechartier, R. Reynaud, A. Cheutin, R. Royer and P. Rumpf, Bull. Soc. Chim. Fr. 1963, 2559. 参考文献:10.1007/s00394-015-1064-1 摘要:Wong W, Ward LC, Fong CW, Yap WN, Brown L. Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats. European Journal of Nutrition. 2015 Oct 08;56(1):133–50. doi: 10.1007/s00394-015-1064-1.