CAS: 2265-93-2; 2,4-Difluoroiodobenzene

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CAS号144025-03-6 2,4-二氟苯硼酸 | CAS号13697-89-7 1,3-二氟-2-碘苯 | CAS号372-18-9 1,3-二氟苯 | CAS号367-25-9 2,4-二氟苯胺 | CAS号446-35-5 2,4-二氟硝基苯 | CAS号75-05-8 乙腈 | CAS号624-75-9 碘乙腈 | CAS号372-18-9 1,3-二氟苯 | CAS号37847-52-2 2,4-二氟联苯 | CAS号85068-35-5 2,4-二氟二苯甲酮 | CAS号106614-28-2 2,4-二氟苯甲酸甲酯 | CAS号20469-63-0 2,4-二甲氧基碘苯 | CAS号458-51-5 2-fluoro-1-iodo... | CAS号450-90-8 4-氟-1-碘-2-甲氧基苯 | CAS号1583-58-0 2,4-二氟苯甲酸 | CAS号76838-87-4 2-(2,4-difluoro...

1,3-二氟苯置于n-碘代丁二酰亚胺,3-硝基苯磺酸水合物体系中,化学反应 12.0H,以70%的收率获得2,4-二氟碘苯
参考文献:具有吸电子取代基的芳烃催化亲电卤化
标题:具有吸电子取代基的芳烃催化亲电卤化
摘要:芳烃的亲电卤化可能是制备芳基卤化物的最简单方法,芳基卤化物是农用化学品,材料和药物中的重要结构基序.然而,芳烃的亲核性被吸电子取代基削弱,其亲电子卤化反应通常需要苛刻的条件,导致底物范围和应用受到限制.因此,在温和条件下卤化含有吸电子基团(ewgs)和复杂生物活性化合物的芳烃一直是一个长期的挑战.在此,我们描述了在温和条件下具有吸电子取代基的芳烃的 Brønsted 酸催化卤化,为芳基卤化物提供了一种有效的方案.布朗斯台德酸与质子溶剂 1,1,1,3,3 的氢键,
Doi:10.1021/jacs.2C06440

专利信息

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9493461-B2
优先权日:2013-02-07
标 题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; LAI ZHONG; NARGUND RAVI; MARCANTONIO KAREN; XIAO DONG; BROCKUNIER LINDA L; ZORN NICOLAS; DANG QUN; PENG XUANJIA; LI PENG
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-12428425-B2
优先权日:2020-05-04
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9243002-B2
优先权日:2013-02-07
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; BROCKUNIER LINDA L; NARGUND RAVI; MARCANTONIO KAREN; ZORN NICOLAS; XIAO DONG; PENG XUANJIA; LI PENG; GUO TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9265773-B2
优先权日:2011-09-08
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:CN-114213300-B
优先权日:2022-01-07
标 题:Mechanochemical synthesis of organic selenium compound