CAS: 231291-22-8; 6-(Trifluoromethyl)Nicotinic Acid

上下游产品

carbon dioxide 5-bromo-2(trifluoromethyl)pyridine 2-(trifluoromethyl)pyridine 2,5-dibromopyridine 6-(trifluoromethyl)nicotinoyl chloride 5-is°Cyanato-2-(trifluoromethyl)pyridine tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate 6-(trifluoromethyl)pyridin-3-ylmethanol

3-氰基-6-三氟甲基吡啶置于盐酸,氨体系中,用 水 用作溶剂,化学反应 13.0H,反应生成6-三氟甲基烟酸
参考文献:Cyanophenyl Derivative
标题:Cyanophenyl Derivative
摘要:该申请涉及一种哌嗪取代的新型氰基苯基衍生物,其中带有芳基,杂环或类似的基团的取代羰酰基或取代磺酰基与哌嗪环上的一个氮原子结合.该申请的化合物具有抗雄激素作用,并可用于预防或治疗前列腺癌,良性前列腺增生等疾病.

专利信息

专利号:US-7371737-B2
优先权日:2004-09-09
标题:2-substituted-6-trifluoromethyl purine derivatives with adenosine-A3 antagonistic activity
发明人：KOCH MELLE; DEN HARTOG JACOBUS A J; KOOMEN GERRIT-JAN; WANNER MARTINUS J; FEENSTRA ROELOF W
权利人:SOLVAY PHARM BV
摘要:The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine-A 3 receptor antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said purine derivatives. n The compounds have the general formula (1) n nwherein the symbols have the meanings given in the specification.

专利号:WO-2006027365-A1
优先权日:2004-09-09
标题:2-substituted-6-trifluoromethyl purine derivatives with adenosine-a3 antagonistic activity
发明人：KOCH MELLE; DEN HARTOG JACOBUS A J; KOOMEN GERRIT-JAN; WANNER MARTINUS J; FEENSTRA ROELOF W
权利人:SOLVAY PHARM BV; KOCH MELLE; HARTOG JACOBUS A J; KOOMEN GERRIT-JAN; WANNER MARTINUS J; FEENSTRA ROELOF W
摘要:The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine -A3 receptor antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said purine derivatives. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

专利号:RU-2026296-C1
优先权日:1988-06-20
标题 :Method of synthesis of nitrogen-containing heterocyclic compounds or their pharmaceutically acceptable salts

专利号:MX-2013015239-A
优先权日:2011-06-30
标题 :DIRECT SYNTHESIS OF COMPOUNDS 18F-FLUOROMETOXI FOR GENERATION OF PET IMAGES AND THE SUPPLY OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF OR - ([18F] FLUOROMETILE) TYPOSINE.

专利号:CN-105622491-A
优先权日:2014-10-28
标 题 :Synthesis of 6-trifluoromethylnicotinaldehyde

专利号:CN-108191855-A
优先权日:2018-01-11
标题 :A new method for the synthesis of imidazoisoquinoline compounds