CAS: 328-70-1; 1-Bromo-3,5-Bis(Trifluoromethyl)Benzene

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CAS号402-31-3 间二三氟甲苯 | CAS号69807-91-6 3,5-双(三氟甲基)苯硼酸频哪醇酯 | CAS号121-91-5 间苯二甲酸(IPA) | CAS号109-65-9 正溴丁烷 | CAS号328-74-5 3,5-二(三氟甲基)苯胺 | CAS号35564-19-3 3,5-双三氟甲基氟苯 | CAS号349-59-7 3,5-双(三氟甲基)苯乙烯 | CAS号556-96-7 5-溴间二甲苯 | CAS号349-60-0 3,5-双三氟甲基苯甲醚 | CAS号349-58-6 3,5-双(三氟甲基)苯酚 | CAS号371-41-5 4-氟苯酚 | CAS号398-23-2 4,4'-二氟联苯 | CAS号1254771-78-2 4-{3,5-bis(trif... | CAS号402-31-3 间二三氟甲苯 | CAS号15979-14-3 BIS[3,5-BIS(TRI...

间二三氟甲苯置于1,3-二溴-5,5-二甲基海因,硫酸体系中,用 溶剂黄146 用作溶剂,化学反应 4.0H,以94%的收率获得3,5-双三氟甲基溴苯
参考文献:3,5-双(三氟甲基)苯乙酮的改进制备方法和3,5-双(三氟甲基)苯基格氏试剂制备中的安全性考虑.
标题:3,5-双(三氟甲基)苯乙酮的改进制备方法和3,5-双(三氟甲基)苯基格氏试剂制备中的安全性考虑.
摘要:开发了一种改进的高效溴化3,5-双(三氟甲基)苯.描述了从前体溴化物安全可靠地制备潜在爆炸性的3,5-双(三氟甲基)苯基格氏试剂和3-三氟甲基苯基格氏试剂的方法.反应系统筛选工具(rsst)和差热分析(dta)研究表明,这些三氟甲基苯基格氏试剂可在失去溶剂接触或适度加热的情况下爆炸.当按照本文所述的方法制备和处理时,这些格氏试剂可以安全地制备并用于高级中间体.
Doi:10.1021/jo026903N

专利信息

专利号:US-6479685-B2
优先权日:1998-01-09
标题 :Metallocene catalysts for synthesis of high-melting polyolefin copolymer elastomers
发明人：WAYMOUTH ROBERT M; KRAVCHENKO RAISA L; MACIEJEWSKI PETOFF JENNIFER; HUNG JOYCE
权利人:TRUSTEES OF THE LELAND STANDAR
摘要:Metallocene catalysts having plural coordination geometries for synthesis of high melting polyolefin copolymers suitable as thermoplastic elastomers. The inventive catalysts comprise unbridged, substituted or unsubstituted cyclopentadienyl metallocene catalysts that are capable of inter-converting between states with different polymerization or copolymerization characteristics, which interconversion is controlled by selecting the substituents of the cyclopentadienyl ligands so that the rate of interconversion of the two states is within several orders of magnitude of the rate of formation of a single polymer chain. Where r i >r f the polymer can be characterized as multiblock; where r i
专利号:US-2008090274-A1
优先权日:2004-12-16
标 题 :Process For The Synthesis Of (S)-1-(3,5-Bis (Trifluoromethyl)-Phenyl-Ethan-1-Ol
发明人：MOORE JEFFREY C; TRUPPO MATTHEW D; POLLARD JENNIFER M; POLLARD DAVID J; STURR MICHAEL G
权利人:MOORE JEFFREY C; TRUPPO MATTHEW D; POLLARD JENNIFER M; POLLARD DAVID J; STURR MICHAEL G
摘要:The present invention is concerned with novel processes for the preparation of (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol (CAS # 30071-93-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6403793-B2
优先权日:2000-06-12
标 题 :Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：PYE PHILIP J; ROSSEN KAI
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1-[3.5-bis(trifluoromethyl)phenyl]ethenyl]oxy]-3-(4-fluorophenyl)-4-(phenylmethyl) mopholine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6255545-B1
优先权日:1999-06-11
标 题 :Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
发明人：CVETOVICH RAYMOND; TSAY FUH-RONG
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)bromobenzene (CAS 328-70-1). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:WO-0076947-A1
优先权日:1999-06-11
标题:Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
发明人：CVETOVICH RAYMOND; TSAY FUH-RONG
权利人:MERCK & CO INC; CVETOVICH RAYMOND; TSAY FUH RONG
摘要:The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)bromobenzene (CAS 328-70-1). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.