CAS: 356783-28-3; 3,6-Difluoropyrazine-2-Carbonitrile

吡嗪酰胺置于四丁基氟化铵,四丁基溴化铵,溶剂黄146,间氯过氧苯甲酸,三氯氧磷体系中,用 乙酸乙酯,氯苯 用作溶剂,化学反应 36.83H,反应生成3,6-二氟-2-吡嗪甲腈
参考文献:法匹拉韦的合成工艺
标题:法匹拉韦的合成工艺
摘要:本发明涉及法匹拉韦的合成工艺,包括有以下步骤:1)将吡嗪化合物溶于有机试剂i中,加入氧化剂m,进行氮氧化反应,得白色固体物质;2)将所得白色固体物质加入到有机试剂ii中进行氯化反应,得淡黄色固体;3)将所得淡黄色固体与干燥的非质子极性溶剂,干燥的氟离子供体试剂,四丁基溴化铵混合均匀,搅拌反应,得淡黄色固体;4)将所得淡黄色固体加入到水中,1,4‑二氧六环和乙酸钠,反应得黄色油状物;5)将所得黄色油状物与浓硫酸混匀,可得目标产物法匹拉韦.本发明的方法涉及的原料简单易得,合成工艺简单,条件温和,经氮氧化,氯化,氟代,水解最终制得6‑氟‑3‑羟基吡嗪‑2‑甲酰胺,具有很好的工业化价值.

专利信息

专利号:WO-2022009036-A1
优先权日:2020-07-06
标题:Synthesis of favipiravir
发明人：DESI REDDY SRINIVAS REDDY; VEDURURI MADHAVA REDDY
权利人:OPTIMUS DRUGS P LTD
摘要:The present invention relates to 6-Fluoro-3-hydroxypyrazine-2-carbonitrile ammonia salt and to an improved and commercially viable process for preparation of Favipiravir using 6-fluoro-3-hydroxypyrazine-2-carbonitrile ammonia salt.

专利号:US-9181203-B2
优先权日:2010-11-12
标题:Substituted pyrazino[2,3-d]isooxazoles as intermediates for the synthesis of substituted pyrazinecarbonitriles and substituted pyrazinecarboxamides
发明人：NAKAMURA KOUKI; MURAKAMI TAKESHI; NAITOU HIROYUKI; HANAKI NAOYUKI; WATANABE KATSUYUKI
权利人:FUJIFILM CORP; TOYAMA CHEMICAL CO LTD
摘要:The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): n nwherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(â•?O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.

专利号:US-2015051396-A1
优先权日:2010-11-12
标题 :Substituted pyrazino[2,3-d]isooxazoles as intermediates for the synthesis of substituted pyrazinecarboxamides

专利号:CN-111349049-B
优先权日:2020-02-28
标 题:Favipiravir and synthesis process of intermediate thereof