CAS: 4415-82-1; Cyclobutylmethanol

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14924-53-9 3721-95-7 765-85-5

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CAS号3721-95-7 环丁基甲酸 | CAS号14924-53-9 环丁烷甲酸乙酯 | CAS号40628-41-9 Methyl cyclobut... | CAS号23519-90-6 环丁-1-烯羧酸 | CAS号89182-08-1 1-Cyclobutene-1... | CAS号15963-49-2 cyclobut-2-en-1... | CAS号81469-29-6 1-chloro-1-(hyd... | CAS号35207-71-7 3-氯环丁烷羧酸 | CAS号51816-01-4 1,1-Cyclobutane... | CAS号5445-51-2 1,1-环丁基二甲酸 | CAS号111857-32-0 ditert-butyl(cy... | CAS号394735-22-9 (4-氨基-1-环丁基-3-羟... | CAS号3721-95-7 环丁基甲酸 | CAS号394730-60-0 波普瑞韦 | CAS号4415-84-3 3-环丁基丙酸 | CAS号96-41-3 环戊醇 | CAS号54509-73-8 ethene | CAS号107-18-6 烯丙醇 | CAS号6540-33-6 环丁基乙酸 | CAS号13295-53-9 Cyclobutylmethy...

环丁基甲酰氯置于乙醚,Sodium体系中,化学反应生成 环丁基甲醇
参考文献:Perkin Junior,W. H.,Journal Of The Chemical Society,1901,Vol. 79,P. 329
标题:Perkin Junior,W. H.,Journal Of The Chemical Society,1901,Vol. 79,P. 329

专利信息

专利号:US-7598399-B2
优先权日:2005-11-30
标 题 :Methods for synthesis of 3-amino-1-arylpropyl indoles
发明人：CONNOLLY TERRENCE JOSEPH; FARRELL ROBERT P; HUMPHREYS ERIC ROY; LYNCH STEPHEN M; SARMA KESHAB
权利人:ROCHE PALO ALTO LLC
摘要:A method comprising:n hydrogenating an indole propionamide compound of formula h nn nwith vitride, to form an aminopropyl indole compound of formula in n nwherein m, Ar, R 1 and R 2 are as defined herein. The compounds prepared by the method of the invention are useful as monoamine reuptake inhibitors useful for treatment of CNS indications.

专利号:US-5637757-A
优先权日:1995-04-11
标 题 :One-pot synthesis of ring-brominated benzoate compounds
发明人：HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
权利人:GREAT LAKES CHEMICAL CORP
摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:WO-9419023-A1
优先权日:1993-02-19
标 题:Cyclobutyl antisense oligonucleotides, methods of making and use thereof
发明人：COOK PHILLIP DAN; BASCHANG GERHARD
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics, therapeutics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.

专利号:WO-2010115869-A1
优先权日:2009-04-03
标 题 :Propofol phosphonyl derivatives, synthesis, and use in long acting formulations
发明人：GONNISSEN YVES RENE JOHANNA PAUL
权利人:SEPS PHARMA N V; GONNISSEN YVES RENE JOHANNA PAUL
摘要:This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH 2 ) P -O-, a single bond, formula (IA), -(CH 2 ) 1-8 -O-X(O)-, and - p is an integer from 1 to 8, - each R 3 and each R 4 is independently selected from the group consisting of C 1-20 alkyl, C 3-12 alkyl, C 3-12 cycloalkyl-C 1-4 alkyl, saturated heterocyclyl and saturated heterocyclyl-C 1-4 alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR 5 , - W is selected from the group consisting of halogen, OH, S(O)H and O - M + wherein M + is a monovalent cation; and - R 5 is selected from the group consisting of hydrogen and C 1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.