CAS: 6338-55-2; 2-(2-(2-Aminoethoxy)Ethoxy)Ethanol

相似化合物

92505-84-5 74654-07-2 139115-92-7

上下游产品

三乙二醇 2,2'-[1,2-Ethanediylbis(Oxy)]Bisethanol 112-27-6
2-[2-(2-叠氮基乙氧基)乙氧基]乙醇 2-[2-(2-Azidoethoxy)Ethoxy]Ethanol 86520-52-7

三乙二醇置于sodium Azide,三苯基膦体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 58.5H,反应生成 2-[2-(2-氨乙氧基)乙氧基]乙醇
参考文献:基于生物素-亲和素相互作用的热敏性树突化共聚物用于蛋白质识别
标题:基于生物素-亲和素相互作用的热敏性树突化共聚物用于蛋白质识别
摘要:摘要通过自由基聚合反应制备了带有树突状低聚乙二醇(oeg)侧基的热敏性生物素化树状共聚物,并研究了基于生物素-亲和素相互作用的蛋白质识别能力.第一代(pg1)和第二代(pg2)树状化共聚物均设计用于检查厚度对生物素与抗生物素蛋白之间相互作用的影响.这些生物素化的圆柱形共聚物继承自oeg树突的出色热响应特性,显示出特征性的热响应行为,从而提供了一个通过高于或低于其相变温度(tcps)的切换温度来捕获抗生物素蛋白的外壳.因此,通过紫外/可见光谱和动态激光散射研究了抗生物素蛋白对聚合物负载的生物素的识别.与pg1的情况相反,共聚物pg2的增加的厚度部分地阻碍并且抑制了抗生物素蛋白在其tcp之下或之上对生物素部分的识别.这证明了树突状聚合物对生物素部分转移到塌陷的聚集体的外围具有显着的构架作用,这应该是蛋白质识别的先决条件.这些新型的热响应共聚物可以为诸如酶或蛋白质的可逆活性控制以及药物或基因的受
DOI:10.1016/j.Cclet.2016.11.016

专利信息

专利号:US-8536375-B2
优先权日:2008-12-22
标题:Synthesis of obtaining modified polyethylene glycol intermediates
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.

专利号:US-11738092-B2
优先权日:2019-12-04
标题:Methods and compositions for synthesis of therapeutic nanoparticles
发明人：WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J
权利人:DANTARI INC
摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

专利号:US-11718596-B2
优先权日:2014-03-19
标题 :Amyloid targeting agents and methods of using the same
发明人：YANG JERRY; THEODORAKIS EMMANUEL A; SARRAF STELLA
权利人:UNIV CALIFORNIA; AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

专利号:US-4996315-A
优先权日:1990-01-16
标 题:Novel synthesis of cyclic compounds
发明人：SPERANZA GEORGE P; LIN JIANG-JEN
权利人:TEXACO CHEMICAL
摘要:Novel cyclic ester-amides having the formula: where R is an alkyl group having from 2 to 5 carbon atoms, and x ranges from 2 to 6 by reacting a polyethylene glycol monoamine having the formula NH2-(CH2CH2O)x-H, where x is as above, with at least one dicarboxylic acid, where the dicarboxylic acid is selected from the group consisting of glutaric, adipic, pimelic acids and mixtures thereof. The a molar ratio of polyethylene glycol monoamine to dicarboxylic acid should be about 1:1. Catalysts may be optionally used, and may include such compounds as titanium alkoxides; and zinc, manganese and antimony salts of carboxylic acids. This method is anticipated to be a useful step in a new preparation of valuable cyclic products.

专利号:US-12065460-B2
优先权日:2021-12-30
标 题 :Compositions and methods for liquid phase oligonucleotide synthesis
发明人：YANG GAOMAI; YAO YUN-CHIAO; YU DAVID; LAU ALDRICH N K
权利人:HONGENE BIOTECH CORP
摘要:Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.

专利号:US-8084589-B2
优先权日:2007-08-31
标 题:Phosphoramidite nucleoside analogs
发明人：BOGDANOV ALEXEI; METELEV VALERIY; TABATADZE DAVID; ZAMECNIK PAUL
权利人:BOGDANOV ALEXEI; METELEV VALERIY; TABATADZE DAVID; ZAMECNIK PAUL; UNIV MASSACHUSETTS; GEN HOSPITAL CORP MASSACHUSETTS
摘要:Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or several reporter groups, organic molecules, bio-molecules, small molecules or other chemical groups at the internucleoside phosphotriesters. Oligonucleotides including the monomers have a number of uses in therapeutic, diagnostic, and research applications.