专利号:US-9051302-B2 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents 发明人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN 权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG 摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
专利号:US-4778805-A 优先权日:1987-06-18 标题:4,7-benzofurandione derivatives useful as inhibitors of leukotriene synthesis 发明人:ADAMS JULIAN; GUINDON YVAN; BELANGER PATRICE C; BELLEY MICHEL L; ROKACH JOSHUA 权利人:MERCK FROSST CANADA 摘要:4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##
专利号:US-10239856-B2 优先权日:2008-01-15 标题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:CN-101990399-B 优先权日:2008-01-15 标 题:Synthesis of dihydroxybenzoic acid lactones as therapeutic agents
专利号:US-2011217335-A1 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:US-2016075677-A1 优先权日:2008-01-15 标 题:Synthesis of resorcylic acid lactones useful as therapeutic agents