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CAS号98-97-5 2-吡嗪羧酸

2-乙基吡嗪置于palladium 10% On Activated Carbon,氢气体系中,用 乙醇 用作溶剂,20.0 °C,344.75 Kpa 条件下,反应 7.0H,以91%的收率获得2-乙基哌嗪
参考文献: Compounds For Regulating Fak And/or Src Pathways[fr] Composés Permettant De Réguler Les Voies Fak Et/ou Src
标题: Compounds For Regulating Fak And/or Src Pathways[fr] Composés Permettant De Réguler Les Voies Fak Et/ou Src
摘要:本申请提供了新颖的可选择替代的融合吡啶和嘧啶双环化合物及其药用可接受盐.还提供了制备这些化合物的方法.通过向受试者投予一种或多种化合物的治疗有效量,这些化合物在共调节fak和/或src活性方面具有用处.通过这样做,这些化合物在治疗与fak和/或src途径失调相关的疾病方面具有有效性.这些化合物作为双重fak和/或src抑制剂表现出优势.可以使用这些化合物治疗各种疾病,包括以炎症或异常细胞增殖为特征的疾病.在一个实施例中,该疾病是癌症.

专利信息

专利号:US-6531591-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:EP-1202998-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:US-8093381-B2
优先权日:2007-05-24
标题:Method of synthesis of fluoroquinolones
发明人：BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS
权利人:BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS; BIOCODEX
摘要:The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and X are as defined in Claim 1.

专利号:EP-1202998-A1
优先权日:1999-07-07
标题:Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates

专利号:WO-0104129-A1
优先权日:1999-07-07
标题:Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates

专利号:US-2009054643-A1
优先权日:2007-05-24
标 题:Novel method of synthesis of fluoroquinolones