CAS: 1448-98-2; N-Carbamoyl-2-Cyanoacetamide

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542-07-4 6972-77-6 41078-06-2

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氰乙酸置于三氯氧磷体系中,化学反应生成氰乙酰脲
参考文献:A Computational Scan For U12-Dependent Introns In The Human Genome Sequence
标题:A Computational Scan For U12-Dependent Introns In The Human Genome Sequence
摘要:在大多数真核生物基因组中发现的 U12 依赖性内含子数量很少,但它们的稀缺性使得准确表征其特性具有挑战性.使用人类基因组序列草稿版本对 U12 依赖性内含子进行计算搜索.人类表达序列证实了人类基因组内有 404 个 U12 依赖性内含子,比之前在所有基因组中鉴定的非冗余 U12 依赖性内含子总数增加了 6 倍.尽管大多数内含子具有 At-Ac 或 Gt-Ag 末端二核苷酸,但仍发现了少量具有令人惊讶的末端多样性的内含子,这表明在人类基因组中发现的许多非规范内含子可能是 U12 依赖性内含子的变体内含子,因此由小剪接体剪接.与 U2 依赖性内含子的比较表明,U12 依赖性内含子组缺乏 U2 依赖性内含子的"短内含子"峰特征.对这个 U12 依赖性内含子集的分析证实了基因组中 U12 依赖性内含子的偏向分布的报告,并允许鉴定几个可变剪接事件以及数量惊人的明显剪接错误.这个新的更大的 U12 依赖性内含子参考集将作为未来研究 U12 剪接体的特性和进化的资源.
Doi:10.1093/nar/29.19.4006

专利信息

专利号:US-3655665-A
优先权日:1965-04-08
标 题 :Process for the production of 5-cyano-uracils
发明人：MEINDL HUBERT; ACKERMANN HANS; KAENEL FRED VON
权利人:CIBA GEIGY AG
摘要:A PROCESS FOR THE PRODUCTION OF 5-CYANO-URACILS IS DESCRIBED COMPRISING (A) RING CLOSING A COMPOUND OF THE FORMULA R1-N(-R2)-C(-R3)=C(-CN)-CO-NH-CO-NH2 IN THE PRESENCE OF AN ALKALINE CONDENSING AGENT AT A TEMPERATURE OF FROM ABOUT 30 TO 150*C., OR (B) REACTING A COMPLEX OF THE FORMULA R3-C(+)(-X)-N(-R1)-R2 Y(-) WITH CYANACETYL UREA, THEREBY OBTAINING THE COMPOUND OF HE ABOVE FORMULA B AND RING CLOSING SAID COMPOUND WITH AN ALKALINE CONDENSING AGENT. THE 5-CYANO-URACILS OBTAINED ARE VALUABLE INTERMEDIATES IN THE SYNTHESIS OF DYESTUFFS.

专利号:US-2012184724-A1
优先权日:2009-09-22
标 题 :Protected monomers and methods of deprotection for rna synthesis
发明人：SIERZCHALA AGNIESZKA B; SMART BRIAN PHILLIP; DELLINGER DOUGLAS J; DELLINGER GERALDINE; MYERSON JOEL; TIMAR ZOLTAN
权利人:SIERZCHALA AGNIESZKA B; SMART BRIAN PHILLIP; DELLINGER DOUGLAS J; DELLINGER GERALDINE; MYERSON JOEL; TIMAR ZOLTAN; AGILENT TECHNOLOGIES INC
摘要:A nucleoside monomer that is protected by a thionocarbamate protecting group and contains one or more 2 H, 13 C, or 15 N isotopes in the ribose and/or base part is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.