CAS: 2516-47-4; Cyclopropylmethylamine

相似化合物

7252-53-1 6228-73-5 18977-45-2

上下游产品

CAS号5500-21-0 环丙基腈 | CAS号186581-53-3 重氮甲烷 | CAS号107-11-9 丙烯胺 | CAS号15687-07-7 环丙西泮 | CAS号6068-90-2 环丙基甲基异硫氰酸酯 | CAS号515140-26-8 4-(环丙基氨基甲酰)苯硼酸 | CAS号26389-63-9 Cyclopropanecar... | CAS号26389-60-6 N-丙基环丙甲胺 | CAS号1489-69-6 环丙甲醛 | CAS号116373-23-0 N-苄基(环丙基)甲胺 | CAS号69565-54-4 (4-氯苯基)-环丙基甲胺 | CAS号756488-62-7 Benzamide,N-(cy... | CAS号842143-89-9 4-(环丙基甲基氨基)-3-硝基吡啶 | CAS号887590-10-5 环丙基甲基-(4-三氟甲基-苯基)-胺

环丙基腈置于sodium Tetrahydroborate,Nickel Dichloride体系中,用 四氢呋喃 用作溶剂,化学反应 16.0H,以53%的收率获得环丙基甲胺
参考文献:一种环丙基甲胺的制备方法
标题:一种环丙基甲胺的制备方法
摘要:本发明涉及环丙基甲胺的制备方法,包括以下步骤:反应容器内加入环丙基腈,二氯化镍和四氢呋喃,开启搅拌,氮气保护下分批加入硼氢化钠,反应温度控制在20‑45°C,反应10‑18小时;反应完毕后降至室温,将反应液加水搅拌,静置分层,分液,水层用二氯甲烷萃取数次,合并有机相,使用无水硫酸钠对有机相干燥,并过滤;将有机相转移到精馏瓶中,常压精馏,收集顶温83‑85oc的产品;对所得不合格前馏再次精馏,合并两次所得无色透明液体,即为目标产物环丙基甲胺.本发明以环丙基腈为起始原料,用硼氢化钠/二氯化镍体系还原氰基合成环丙基甲胺.该合成方法原料便宜,反应条件温和,操作简单,安全可靠,后处理简单,适合工业化生产.

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-9695169-B2
优先权日:2012-05-31
标 题:Synthesis of heterocyclic compounds
发明人：IBRAHIM PRABHA N
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-2009101516-A1
优先权日:2007-09-20
标题:Methods and apparatus for the synthesis of useful compounds
发明人：SUIB STEVEN LAWRENCE; HU BOXUN; STANCOVSKI VICTOR
权利人:UNIV CONNECTICUT; CATELECTRIC CORP
摘要:The present invention relates to methods and apparatus for activation of a low reactivity, non-polar chemical compound. In one example embodiment, the method comprises introducing the low reactivity chemical compound to a catalyst. At least one of (a) an oxidizing agent or a reducing agent and (b) a polar compound is provided to the catalyst and the chemical compound. An alternating current is applied to the catalyst to produce an activation reaction in the chemical compound. This activation reaction produces a useful product. The present invention also relates to a method for oxidizing aromatic compounds by electrocatalysis to oxidized products.