CAS: 2530-26-9; 3-Nitropyridine

上下游产品

pyridine sulfuric acid 2-Chloro-3-nitropyridine 2-Hydrazino-3-nitropyridine 3-nitro-1-phenacyl-pyridinium; bromide 3-nitro-1-(4-nitro-benzyl)-pyridinium; bromide pyridin-3-ylamine 3-nitropyridine N-oxide

3-(三甲基锡烷基)-吡啶置于dinitrogen Tetraoxide体系中,用 四氯化碳,二甲基亚砜 用作溶剂,化学反应 16.0H,以2%的收率获得3-硝基吡啶
参考文献:用四硝基甲烷和四氧化二氮硝化杂芳基三甲基锡:机理方面,范围和限制
标题:用四硝基甲烷和四氧化二氮硝化杂芳基三甲基锡:机理方面,范围和限制
摘要:当杂芳基锡的 Homo 能量足够高以允许形成相应的自由基阳离子时,四硝基甲烷 (Tnm) 或四氧化二氮对 2-(三甲基甲锡烷基) 杂芳烃的硝化已被证明是可能的.该反应通过杂芳基锡和 Tnm 之间的电荷转移复合物进行,然后是单电子转移,在太阳灯照射下增强.因此,通过该方法获得了2-硝基苯并[b]呋喃,2-硝基苯并[b]噻吩,2-硝基吡啶和2-硝基吲哚.然而,由于 Homo 轨道的低能量,2-甲锡烷基化嘧啶或甲锡烷基化 1,3,5-三嗪的硝化已被证明是不可能的.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2003)
Doi:10.1002/ejoc.200210611

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:US-2015359913-A1
优先权日:2013-01-25
标题:Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides
发明人：REINER THOMAS; LEWIS JASON STUART; WEISSLEDER RALPH; ZEGLIS BRIAN
权利人:SLOAN KETTERING INST CANCER; GEN HOSPITAL CORP
摘要:This invention is in the field of labeled peptide construction for medical treatment and analysis. The invention relates to synthetic labeled peptide compositions, methods of synthesis, and methods of use for the synthetic labeled peptide compositions for medical treatment, imaging, and research purposes.

专利号:WO-2011048029-A1
优先权日:2009-10-20
标题:Cyclic peptide synthesis
发明人：HUSBYN METTE
权利人:GE HEALTHCARE AS; HUSBYN METTE
摘要:The present invention relates to an improved method of synthesis of cyclic peptides comprising 2 or more disulfide bonds, using the reagent bispyridyl disulfide. Also disclosed is the application of the method to specific cMet-targeting peptides.

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).