CAS: 26311-45-5; 4-Pentylbenzoic Acid

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戊基苯置于jones Reagent体系中,用 丙酮,三氟乙酸 用作溶剂,化学反应 0.5H,反应生成4-正戊基苯甲酸
参考文献:新的有效的白三烯c4和d4拮抗剂.1.合成与构效关系.
标题:新的有效的白三烯c4和d4拮抗剂.1.合成与构效关系.
摘要:(p-戊基肉桂酰基)邻氨基苯甲酸(3A)对ltd4-诱导的豚鼠回肠平滑肌收缩和ltc4诱导的豚鼠支气管收缩具有中等程度的拮抗活性.对3A的疏水部分(肉桂酰基部分)和亲水部分(邻氨基苯甲酸酯部分)进行了修饰.揭示了一系列的8-(苯甲酰基氨基)-2-四唑-5-基-1,4-苯并二恶烷和8-(苯甲酰基氨基)-2-四唑-5-基-4-氧代-4H-1-苯并吡喃.白三烯c4和d4的有效拮抗剂.在这两个系列中,Ono-Rs-347(18K)和ono-Rs-411(19H)分别是最有效和口服活性的拮抗剂.讨论了构效关系.
Doi:10.1021/jm00396A013

专利信息

专利号:US-9000209-B2
优先权日:2011-07-22
标题:Method of regioselective synthesis of substituted benzoates
发明人：KRAUS GEORGE A
权利人:KRAUS GEORGE A; UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

专利号:WO-2019190945-A1
优先权日:2018-03-29
标 题 :Biosynthesis of olivetolic acid
发明人：GONZALEZ RAMON; TAN ZAIGAO; CLOMBURG JAMES M
权利人:UNIV RICE WILLIAM M
摘要:We present a biosynthetic approach to engineer novel microbes, such as Escherichia coli , for the production of olivetolic acid and other aromatic polyketides, as well as various downstream products that can be made therefrom. We engineered an E. coli strain that synthesizes olivetolic acid from a principle carbon source in vivo by expressing olivetolic acid synthase and olivetolic acid cyclase with the required modules of a β-oxidation reversal for hexanoyl-CoA generation. Further, we engineered an E. coli strain that synthesizes olivetolic acid which integrated additional auxiliary enzymes for increasing both hexanoyl-CoA and malonyl-CoA, enabling the synthesis of about 75 mg/L olivetolic acid and a productivity of 9.3 mg/hr olivetolic acid produced per gram dry weight of cells.

专利号:US-2014288324-A1
优先权日:2011-07-22
标 题:Method of regioselective synthesis of substituted benzoates

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人：TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:WO-2013015918-A1
优先权日:2011-07-22
标 题 :Method of regioselective synthesis of substituted benzoates