CAS: 2919-23-5; Cyclobutanol

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20117-47-9 13221-54-0 63518-47-8

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CAS号2516-33-8 环丙基甲醇 | CAS号1191-95-3 环丁酮 | CAS号70458-21-8 cyclobutanecarb... | CAS号76387-45-6 1,3-bis(cyclopr... | CAS号42392-30-3 cyclobutanecarb... | CAS号27852-78-4 cyclobutylcarbi... | CAS号2892-99-1 (1-methylcycloh... | CAS号67-63-0 异丙醇 | CAS号17085-88-0 diethyl propyli... | CAS号123-72-8 正丁醛 | CAS号4399-47-7 溴化环丁烷 | CAS号33574-02-6 (碘甲基)环丙烷 | CAS号927-73-1 4-氯-1-丁烯 | CAS号1120-57-6 环丁基氯 | CAS号5911-08-0 氯甲基环丙烷 | CAS号18593-33-4 methoxycyclobutane | CAS号189956-41-0 2-环丁氧基乙酸 | CAS号96-48-0 γ-丁内酯 | CAS号1191-95-3 环丁酮 | CAS号141-82-2 丙二酸

环丁酮置于diplogelasinospora Grovesii Imi 171018 Cells体系中,化学反应 72.0H,反应生成环丁醇
参考文献:Diplogelasinospora Grovesii Imi 171018,一种用于立体选择性还原酮的新型全细胞生物催化剂
标题:Diplogelasinospora Grovesii Imi 171018,一种用于立体选择性还原酮的新型全细胞生物催化剂
摘要:筛选了416株(71细菌菌株,45放线菌,59酵母,60担子菌,33海洋真菌和148丝状真菌)以寻找在没有氧化酶活性的情况下表现出还原酶活性的微生物.分离出一种新的微生物,Diplogelasinospora Grovesii Imi 171018(一种非病原菌菌株),它在还原环酮方面显示出很高的活性和立体选择性.选择该真菌是由于其对单环和双环酮的选择性以及易于培养的条件,从而易于扩大规模.与传统啤酒酵母相比,格罗夫氏杆菌在还原传统酮方面更活跃.Ii型(来自sigma),可以在高酮浓度(<60 Mm)存在的情况下工作.为了说明作为微生物醇还原酶底物的羰基化合物的空间和电子性质,已应用比较分子场分析(comfa).Comfa模型具有高度预测性(q 2 = 0.549),可用于解释和预测可被该微生物还原或无法还原的酮的结构.
Doi:10.1016/j.Tetasy.2004.01.034

专利信息

专利号:US-2024092821-A1
优先权日:2020-03-31
标题:Synthesis of oligonucleotides and related compounds
发明人：ZHONG MINGHONG; JIN YI; GALA DINESH; PRHAVC MARIJA
权利人:JANSSEN BIOPHARMA INC
摘要:Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide subunit on a cleavable support having an azidomethyl moiety and a nucleoside phosphoramidite or an oligonucleotide phosphoramidite, capping, oxidation/thiolation and deblocking; followed by orthogonal cleavage of the azidomethyl support while keeping all other protecting groups intact. The method can be used in combination with a support moiety for either solid phase or liquid phase oligo synthesis. The soluble support facilitates homogeneous reactions and efficient separations by simple precipitation. The methods also provide novel intermediates useful in the synthesis of oligonucleotide conjugates.

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

专利号:US-2010087658-A1
优先权日:1996-08-06
标 题 :Methods and intermediates for synthesis of selective dpp-iv inhibitors
发明人：CAMPBELL DAVID ALAN; LEITAO EMILIA P T; WU ZHEN-PING; WANG PENG
权利人:PHENOMIX CORP
摘要:Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.

专利号:US-9000209-B2
优先权日:2011-07-22
标题:Method of regioselective synthesis of substituted benzoates
发明人：KRAUS GEORGE A
权利人:KRAUS GEORGE A; UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.