CAS: 455-67-4; 1-(3-Fluorophenyl)Propan-1-One

上下游产品

CAS号701-38-2 1-(3-氟苯基)丙醇 | CAS号403-54-3 3-氟苯甲腈 | CAS号925-90-6 乙基溴化镁 | CAS号74-96-4 溴乙烷 | CAS号462-06-6 氟苯 | CAS号123-62-6 丙酸酐 | CAS号456-48-4 3-氟苯甲醛 | CAS号458-02-6 3-氟苯并乙醛 | CAS号86639-52-3 7-乙基-10羟基喜树碱 | CAS号97682-44-5 伊立替康 | CAS号100286-90-6 盐酸依立替康 | CAS号924648-17-9 1-(5-fluoro-2-n... | CAS号92821-83-5 2′-溴-3-氟苯丙酮 | CAS号453518-19-9 1-(5-hydroxy-2-...

3-氟苯甲醛肟置于乙酸酐,Magnesium体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.5H,反应生成 3-氟苯丙酮
参考文献:Scalable Synthetic Route To 2-Amino-5-Hydroxypropiophenone: Efficient Formal Synthesis Of Irinotecan
标题:Scalable Synthetic Route To 2-Amino-5-Hydroxypropiophenone: Efficient Formal Synthesis Of Irinotecan
摘要:2-Amino-5-Hydroxypropiophenone,A Key Precursor In The Total Synthesis Of Irinotecan,Has Been Synthesized. Regioselective Nitration And A Snar Displacement Are The Key Steps Involved In This Strategy,Which Is High Yielding,Is Economical,And Has Been Performed On A Plant Scale.
DOI:10.1080/00397911.2012.658947

专利信息

专利号:US-7608740-B2
优先权日:2005-08-03
标 题 :Method of synthesizing key intermediates for the production of camptothecin derivatives
发明人：RAO RAMAKRISHNA; RAO ALLA VENKATA RAMA
权利人:AVRA LAB PVT LTD
摘要:The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skeleton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

专利号:US-11434196-B2
优先权日:2019-01-15
标 题 :Process for preparation of 2-Amino-5-hydroxy propiophenone
发明人：VASIREDDI UMA MAHESWER RAO; KINTALI VENKATA RAMANA; DADI JAGADEESWARA RAO; KATKURI RAJ KOTI; TUMMU SRIDHAR
权利人:LAURUS LABS LTD
摘要:The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).

专利号:US-5866723-A
优先权日:1991-09-25
标 题 :Benzoyl derivatives and synthesis thereof
发明人：HAMPER BRUCE C; LESCHINSKY KINDRICK L
权利人:MONSANTO CO
摘要:The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.

专利号:CN-106083686-B
优先权日:2016-06-01
标题 :The method of alpha-brominated acetophenone oxime ether synthesis 2,4- diaryl pyrrole class compound