CAS: 562-10-7; Butanedioic Acid, Compd. Withn,N-Dimethyl-2-[1-Phenyl-1-(2-Pyridinyl)Ethoxy]Ethanamine (1:1)Other Ca Index Names:Ethanamine, N,N-Dimethyl-2-[1-Phenyl-1-(2-Pyridinyl)Ethoxy]-,Butanedioate (1:1)

上下游产品

succinic acid doxylamine iodobenzene 2-acetylpyridine2-[1-(dimethylammonioethoxy)-1-phenylethyl]pyridinium tetrachlor°Cuprate(II) [2-(1-(dimethylammonioethoxy)-1-phenylethyl)pyridinium] tetrachlor°Cobaltate(II) [2-(1-(dimethylammonioethoxy)-1-phenylethyl)pyridinium] tetrachlorozincate(II)

碘苯置于盐酸,碘,Sodium Amide,Magnesium体系中,用 5,5-Dimethyl-1,3-Cyclohexadiene,乙醚,水,丙酮 作为反应溶剂,化学反应 24.5H,反应生成 琥珀酸多西拉敏
参考文献:一种琥珀酸多西拉敏的制备方法
标题:一种琥珀酸多西拉敏的制备方法
摘要:本发明涉及一种琥珀酸多西拉敏的制备方法,首先选用碘苯和镁反应生成的grignard试剂与2-乙酰吡啶反应反应生成2-吡啶基苯基甲基甲醇,经重结晶纯化,然后2-吡啶基苯基甲基甲醇依次同氨基钠和2-二甲氨基氯乙烷反应,得到多西拉敏,最后多西拉敏与琥珀酸成盐反应得到琥珀酸多西拉敏.本制备工艺反应效率高,成本较低,适合工业化大生产.

专利信息

专利号:US-2022125711-A1
优先权日:2020-10-23
标题 :Cannabinoid-containing oral thin film formulations
发明人：BAJAJ AKHIL; WEBB SKYLER; HOOSEIN SHEHZAD; RASHKOW ANDREW
权利人:JDEM PROPERTIES LLC
摘要:The methods disclosed herein permit the synthesis of cannabinoid-containing oral thin film (OTF) strips that also contain caffeine or multiple additional active ingredients. Selection of film forming agents based on water usage coupled with low temperature mixing and low temperature drying may in various embodiments permit the incorporation of up to five additional ingredients into a cannabinoid containing OTF product.

专利号:CN-114524765-A
优先权日:2021-12-27
标题 :A kind of method for base-catalyzed synthesis of doxylamine succinate

专利号:US-2005053642-A1
优先权日:2000-08-23
标题:Biocompatible materials
发明人：ULBRICHT MATHIAS; THOM VOLKMAR; JANKOVA KATJA; ALTANKOV GEORGE; JONSSON GUNNAR
摘要:The present invention teaches a novel approach of creating biocmpatible surfaces, said surfaces being capable of functionally interact with biological material. SAid biocompatible surfaces comrise at least two comonents, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, which, in a cooperativity, form together the novel biocoompatible surfaces. The novel approach is ased on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of said hydrophilic and flexible macromolecules, exhibiting a pronounced excluded volume. The htus formed two component surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by: i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecules(s) is in turn determined by synthesis. AMount and conformation and thus also biological activity of biological material (as e.g. polypeptides) which contact the novel biocompatible surface, is determined and maintained by the cooperative action of the underlying hydrophobic substratum and the macromolecular layer. In this way it becomes possible to maintain and control biological interactions between said contacted polypeptides and other biological compounds as e.g. cells, antibodies and the like. Consequently, the present invention aims to reduce and/or eliminate the deactivation and/or denaturation associated with the contacting of polypeptides and/or other biological material to a hydrophobic substratum surface.

专利号:CN-110498764-B
优先权日:2019-09-25
标 题:A kind of synthesis method of doxylamine succinate