专利号:US-2004249170-A1 优先权日:2002-01-24 标 题 :Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine 发明人:BORGHESE ALFIO 摘要:This invention provides a process for the synthesis of(S)-3-Methylamino-1-2-thienyl)-1-propanol, a key intermediate in the synthesis of duloxetine.
专利号:US-5973157-A 优先权日:1997-04-18 标题 :Process for the synthesis of 1,7-diarly or heteroaryl-heptane-4-ols and new synthetic intermediates 发明人:STIVANELLO MARIANO 权利人:FABBRICA ITALIANA SINTETICI SPA 摘要:This invention offers a process for the synthesis of a compound of the formula ##STR1## wherein R' is a phenyl, a substituted phenyl, a heterocyclic aromatic group, a heterocyclic aromatic substituted group, a linear or branched alkyl group, or a cycloalkyl group. n The invention also comprises the following compounds of a formula 1' and 2' as useful new synthesis intermediates. ##STR2## wherein R is a phenyl, a substituted phenyl, an alkyl, a cycloalkyl and X is Cl, Br, I, F, CH 3 SO 3 , p--CH 3 --C 6 H 4 --SO 3 .
专利号:US-5550267-A 优先权日:1994-06-14 标 题:Process for the synthesis of haloalkylferrocenes 发明人:GRAINDORGE HERVE; MONDET JEAN-CLAUDE; VINCENT CHARLES-HENRY 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The present invention relates to a process for the synthesis of haloalkylferrocenes, comprising a first stage of reaction, in the presence of AlCl 3 as catalyst and in organic solvent medium, of a carboxylic acid halide or anhydride with ferrocene or an alkylferrocene. n After this stage, without prior isolation of the intermediate compound, a metal hydride is added to the reaction mixture. n The haloalkylferrocenes are particularly useful as intermediates in the synthesis of combustion catalysts for propellants.
专利号:EP-2644590-A1 优先权日:2012-03-30 标 题:Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.
专利号:US-2025206736-A1 优先权日:2019-11-14 标题 :Synthesis of kras g12c inhibitor compound 发明人:CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN 权利人:AMGEN INC 摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
专利号:US-11198684-B2 优先权日:2017-07-28 标 题 :Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same 发明人:OH SANG-HO; KHOO JA-HEOUK; LIM JONG-CHUL; LEE DOO-BYUNG; LEE JUNG-AE; LEE JUN-SUP; JU HYUN; SHIN WOO-SEOB; JEON SANG-SEOL 权利人:YUHAN CORP 摘要:The present invention provides intermediates useful for the synthesis of an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors; and processes for preparing the same. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 346. 摘要:Camp, J. E., Science of Synthesis Knowledge Updates, (2012) 1, 339. 摘要:Huy, P.; Czekelius, C., Science of Synthesis Knowledge Updates, (2019) 2, 200. 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026).