CAS: 626-88-0; 1-Bromo-4-Methylpentane

相似化合物

35354-37-1 6570-92-9 52648-04-1

上下游产品

4-Methyl-1-pentanol 4-Methyl-1-pentene 4-Methylpentanoic acid i-pentyl bromide 2-(4-methylpentyl)cyclohexanone 6-methyl-2-heptanol 1-isohexyl-2-oxo-cyclohexanecarboxylic acid ethyl ester 4-methylhexan-1-ol

4-甲基-1-戊烯置于氢溴酸体系中,化学反应生成 1-溴-4-甲基戊烷
参考文献:Free-Radical Isomerization. I. Novel Rearrangement Of Vinyl Radicals
标题:Free-Radical Isomerization. I. Novel Rearrangement Of Vinyl Radicals
摘要:
DOI:10.1021/ja00991A017

专利信息

专利号:US-2024327320-A1
优先权日:2023-02-06
标 题:Novel routes of chemical synthesis of 20s(oh)d3, 20s,25(oh)2d3, 20s,23s(oh)2d3, and 20s,23r(oh)2d3 and their modification of the immune activity of pbmcs
发明人：SLOMINSKI ANDRZEJ; BRZEMINSKI PAWEL; FABISIAK ADRIAN
权利人:UNITED STATE GOVERNMENT AS REPRESEN TED BY THE DEPT OF VETERANS AFFAIRS; UNIV OF WARSAW
摘要:The present disclosure is concerned with methods of making hydroxy derivatives of vitamin D3, compounds useful as intermediates in the preparation of the hydroxy derivatives, and methods of making the intermediates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-6989450-B2
优先权日:2000-10-13
标 题:Synthesis of epothilones and related analogs
发明人：AVERY MITCHELL A
权利人:UNIV MISSISSIPPI
摘要:The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: n n nand stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.

专利号:US-5444174-A
优先权日:1992-02-26
标题 :16-membered macrolide derivative having sustained antibacterial activity in plasma, synthesis intermediate thereof and process for producing the same
发明人：AJITO KEIICHI; KURIHARA KENICHI; ISHIZUKA TSUNEO; HARA TETSURO; USUI TAKAYUKI; SHIBAHARA SEIJI
权利人:MEIJI SEIKA KAISHA
摘要:16-membered macrolide compounds wherein both of hydroxyl groups at the 3''- and 4''-positions form ether bonds together with two alkyl groups which are either the same or different from each other is useful as an antibacterial agent. The macrolide compounds represented by formula (I) are prepared by chemically modifying midecamycin A3 to obtain a synthesis intermediate of the formula (II), which is further chemically modified. (I)

专利号:US-2012258938-A1
优先权日:2008-02-28
标题:Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof
发明人：SLOMINSKI ANDREJ; TUCKEY ROBERT C; TANG EDITH; TIEU ELAINE; NGUYEN MINH; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; LU YAN; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E
权利人:SLOMINSKI ANDREJ; TUCKEY ROBERT C; TANG EDITH; TIEU ELAINE; NGUYEN MINH; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; LU YAN; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E
摘要:Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein.

专利号:US-2006122240-A1
优先权日:2002-11-05
标题 :Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof
发明人：SEMPLE GRAEME; SKINNER PHILIP J; CHERRIER MARTIN C; WEBB PETER; TAMURA SUSAN Y
权利人:ARENA PHARM INC
摘要:The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

专利号:US-2014200201-A1
优先权日:2008-02-28
标题 :Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof
发明人：SLOMINSKI ANDRZEJ T; TUCKEY ROBERT C; ZBYTEK BLAZEJ; ZMIJEWSKI MICHAL A; NGUYEN MINH NGOC; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E; SWEATMAN TREVOR W
权利人:SLOMINSKI ANDRZEJ T; TUCKEY ROBERT C; ZBYTEK BLAZEJ; ZMIJEWSKI MICHAL A; NGUYEN MINH NGOC; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E; SWEATMAN TREVOR W
摘要:Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in Tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the P450scc (CYP11A1) or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.