CAS: 62935-72-2; 2-(7-Methoxy-2-Oxo-2H-Chromen-4-yl)Acetic Acid

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O-methylresorcine acetonedicarboxylic acid 2-(7-hydroxy-2-ox°Chromen-4-yl)acetic acid dimethyl sulfate (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid ethyl ester 4-(bromomethyl)-7-methoxycoumarin H-chromen-4-yl)-acetylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester4-{4-bromo-2-[2-(7-methoxy-2-oxo-2H-chromen-4-yl)-acetylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester N-[(5-benzoxy-4-oxo-4H-pyran-2-yl)methyl]-2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamide

1,3-丙酮二羧酸二乙酯置于sodium Hydroxide,Amberlyst-15 Cation-Exchange Resin体系中,用 乙醇,甲苯 作为反应溶剂,化学反应 12.0H,反应生成 7-甲氧基-2-氧代-2H-1-苯并吡喃-4-乙酸
参考文献:Design,Synthesis,Physicochemical Properties,And Evaluation Of Novel Iron Chelators With Fluorescent Sensors
标题:Design,Synthesis,Physicochemical Properties,And Evaluation Of Novel Iron Chelators With Fluorescent Sensors
摘要:The Synthesis Of A Range Of Novel 3-Hydroxypyridin-4-Ones And 3-Hydroxypyran-4-Ones Linked With Different Coumarin Substituents Is Described. These Compounds Have Been Developed In Order To Provide A Series Of Molecular Probes For The Quantification Of Intracellular Labile Iron Pools. An Evaluation Of The Effect Of Iron(Iii) On Fluorescence Intensity Was Undertaken. Chelation Of Iron(Iii) Causes Quenching Of Fluorescence. The Relationship Between Iron(Iii) Concentration And The Extent Of Fluorescence Quenching Indicates That The Metal Is Chelated In A Complex With A Metal-To-Ligand Stoichiometry Of 1:3. The Fluorescence Of Hydroxypyridinone Compounds Was Found To Be More Efficiently Quenched By Iron(Iii) Than Were The Hydroxypyranones. The Metal-To-Ligand Stoichiometry At Which Maximum Quenching Is Observed Was Found To Depend On The Site At Which Coumarin Is Attached. The Efficiency Of Fluorescence Quenching By Iron(Iii) Is Markedly Influenced By Solvent Polarity And Ph. The Permeability Of Two Representative Fluorescent Chelators Across Human Erythrocyte Ghost Membranes Was Investigated. The Rate Of Permeability For A Series Of Probes Was Found To Be Related To The Corresponding Clogp Values.
DOI:10.1021/jm049751S

专利信息

专利号:US-2013143251-A1
优先权日:2010-06-01
标题:Expeditious synthesis of ubiquitinated peptide conjugates
发明人：BRIK ASHRAF; KUMAR AJISH; ERLICH LESLIE; SPASSER LIAT
权利人:BRIK ASHRAF; KUMAR AJISH; ERLICH LESLIE; SPASSER LIAT; UNIV BEN GURION
摘要:The present invention discloses a process for preparing ubiquinated peptide conjugates comprising a ubiquitin peptide residue UR attached at its C-terminus to a substrate peptide via a native isopeptide bond, this process comprising combining Native Chemical Ligation (NCL) and solid phase peptide synthesis (SPPS). Further are disclosed ubiquinated peptide conjugates containing a native isopeptide bond, as well as various uses thereof.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:EP-0383803-B1
优先权日:1987-10-28
标题 :Oligonucleotide-polyamide conjugates
发明人：HARALAMBIDIS JIM; TREGEAR GEOFFREY WILLIAM
权利人:HOWARD FLOREY INST OF
摘要:Oligonucleotide-polyamide conjugates of the formula X-L-Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

专利号:US-5525465-A
优先权日:1987-10-28
标 题:Oligonucleotide-polyamide conjugates and methods of production and applications of the same
发明人：HARALAMBIDIS JIM; TREGEAR GEOFFREY W
权利人:FLOREY HOWARD INST
摘要:Oligonucleotide-polyamide conjugates of the formula X--L--Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis