专利号:WO-2021038581-A1 优先权日:2019-08-30 标题 :A one step synthesis of 2-substituted benzo[b]thiophenes 发明人:SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI 权利人:INDIAN INST TECH MADRAS 摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.
专利号:US-6472531-B1 优先权日:1994-09-19 标题 :Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 发明人:LABELL ELIZABETH SMITH; MCGILL JOHN MCNEILL; MILLER RANDAL SCOT 权利人:LILLY CO ELI 摘要:The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]-benzo[b]thiophene hydrochloride, as well as processes for their preparation.
专利号:US-2016318862-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds 发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
专利号:US-4380635-A 优先权日:1981-04-03 标 题 :Synthesis of acylated benzothiophenes 发明人:PETERS MARY K 权利人:LILLY CO ELI 摘要:A group of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)benzoyl]benzo[b]thiophenes are prepared by acylation of a methyl-protected starting compound followed by demethylation in a single reaction mixture.
专利号:US-5936128-A 优先权日:1993-11-19 标题:5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents 发明人:ELLSWORTH EDMUND LEE; LUNNEY ELIZABETH; TAIT BRADLEY DEAN 权利人:WARNER LAMBERT CO 摘要:The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
专利号:US-2023159678-A1 优先权日:2020-06-19 标题:Methods of polymerization with aromatic thiol initiators 发明人:BOWMAN CHRISTOPHER N; LOVE DILLON 权利人:UNIV COLORADO REGENTS 摘要:Provided herein are methods of using aryl thiols as photoinitiators. The thiol compounds are useful as oxygen insen-sitive photoinitiators for applications such as bulk polymerizations and for specialty polymer synthesis by preparing aromatic thiol functionalized macroinitiators.
摘要:Ohno, H.; Tomioka, K., Science of Synthesis, (2008) 44, 166. 摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 336. 摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 422. 摘要:Tsubouchi, A., Science of Synthesis Knowledge Updates, (2016) 2, 329. 摘要:Eichman, C. C.; Stambuli, J. P., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 383.