CAS: 1609-47-8; Diethyl Pyrocarbonate

相似化合物

623-53-0 24424-99-5 115491-93-5

上下游产品

CAS号541-41-3 氯甲酸乙酯 | CAS号124-30-1 十八胺 | CAS号5536-61-8 甲基丙烯酸钠 | CAS号64-17-5 乙醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号483-18-1 依米丁 | CAS号67-66-3 氯仿 | CAS号424-36-2 九氟戊酸乙酯 | CAS号544-35-4 亚油酸乙酯 | CAS号41430-70-0 十三氟庚酸乙酯 | CAS号32996-16-0 吲哚-5-甲酸乙酯 | CAS号93-89-0 苯甲酸乙酯 | CAS号14619-42-2 ethyl 4-methyl-... | CAS号180468-42-2 (1S)-1-苯基-1,2,3... | CAS号94-30-4 4-甲氧基苯甲酸乙酯 | CAS号1847-84-3 Carbonic acid, ...

氯甲酸乙酯置于四丁基溴化铵 Sodium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,以93%的收率获得焦碳酸二乙酯
参考文献:利用相转移反应的羧酸和碳酸酐的新合成
标题:利用相转移反应的羧酸和碳酸酐的新合成
摘要:使用液-液相转移条件,酰氯和烷基氯甲酸酯与一摩尔当量的氢氧化钠平稳反应,得到高产率的相应的对称羧酸和碳半酯酸酐.用这种方法很容易制得不稳定的酸酐,如4-硝基苯甲酸酐,2-糠醛和甲基丙烯酸酐,否则很难获得.该反应机理似乎不涉及将一半的酰氯中间水解为相应的羧酸钠.
Doi:10.1016/s0040-4020(01)81698-7

专利信息

专利号:US-6180347-B1
优先权日:1997-02-03
标 题:Method for monitoring transcriptional synthesis of RNA
发明人：IIDA YUKARI; KOSHIMOTO HIROYUKI; KONDO SATOSHI; TSUJI AKIHIKO
权利人:LAB MOLECULAR BIOPHOTONICS
摘要:This invention provides a method for monitoring the transcriptional synthesis of RNA, and to an apparatus therefor. Specifically, the invention resides in monitoring the initiation and termination of a transcription reaction for RNA synthesis, as well as the synthesis of full-length RNA by measuring the fluorescence of a pair of oligonucleotide probes of two types having a base sequence that continuously hybridizes to a part of a base sequence of the RNA synthesized by transcription, the pair of oligonucleotide probes comprising a donor probe labeled with an energy donor fluorescent molecule and an acceptor probe labeled with an energy acceptor fluorescent molecule.

专利号:US-8299206-B2
优先权日:2007-11-15
标题:Method of synthesis of morpholino oligomers
发明人：FOX CHRISTINA MARY JOSEPHINE; WELLER DWIGHT D
权利人:FOX CHRISTINA MARY JOSEPHINE; WELLER DWIGHT D; AVI BIOPHARMA INC
摘要:Improved methods are described for solid-phase synthesis of morpholino oligomers, in which a protected morpholino ring nitrogen is deprotected between coupling steps using a heterocyclic amine salt in a trifluoroethanol-containing solvent, where the salt is a salt of a heterocyclic amine, having a pKa in the range of 1-4 in its protonated form, with an acid selected from a sulfonic acid, trifluoroacetic acid, and hydrochloric acid. Examples are 3-chloropyridinium methanesulfonate (CPM) and 4-cyanopyridinium trifluoroacetate (CYTFA).

专利号:US-8076476-B2
优先权日:2007-11-15
标 题 :Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
发明人：REEVES MATTHEW DALE; WELLER DWIGHT D; LI YONGFU
权利人:REEVES MATTHEW DALE; WELLER DWIGHT D; LI YONGFU; AVI BIOPHARMA INC
摘要:Morpholino compounds are provided having the structure: n nwheren R 1 is selected from the group consisting of lower alkyl, di(lower alkyl)amino, and phenyl; R 2 is selected from the group consisting of lower alkyl, monocyclic arylmethyl, and monocyclic (aryloxy)methyl; R 3 is selected from the group consisting of triarylmethyl and hydrogen; and Y is selected from the group consisting of: a protected or unprotected hydroxyl or amino group; a chlorophosphoramidate group; and a phosphorodiamidate linkage to the ring nitrogen of a further morpholino compound or a morpholino oligomer. Such compounds include doubly protected morpholino guanine (MoG) monomers. Also described is their use in synthesis of morpholino oligomers.

专利号:US-4212828-A
优先权日:1978-04-14
标 题:Novel process for asymmetric synthesis of optically active 2-alkanoyl-1,2,3,4-tetrahydro-2-naphthol compounds
发明人：KOGA KENJI; TERASHIMA SHIRO
权利人:SUMITOMO CHEMICAL CO
摘要:A process for asymmetric synthesis of optically active 2-alkanoyl-1,2,3,4-tetrahydro-2-naphthol compounds of the formula: ##STR1## from L-proline or its ester and the following carboxylic acid of the formula: ##STR2## or its reactive derivative through the following intermediary compounds in order: ##STR3##

专利号:US-4400550-A
优先权日:1982-02-12
标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal
发明人：BISHOP CLYDE E; MORROW GARY W
权利人:ALBANY INT CORP
摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人：TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.