CAS: 18438-38-5; 2-(Methylthio)Pyridine

相似化合物

73018-10-7 51933-78-9 19006-76-9

上下游产品

CAS号2637-34-5 2-巯基吡啶 | CAS号74-88-4 碘甲烷 | CAS号109-04-6 2-溴吡啶 | CAS号624-92-0 二甲基二硫醚 | CAS号67-68-5 二甲基亚砜 | CAS号21948-75-4 2-(甲基亚硫酰基)吡啶 | CAS号616-38-6 碳酸二甲酯 | CAS号109-09-1 2-氯吡啶 | CAS号5188-07-8 甲硫醇钠 | CAS号3115-68-2 四丁基溴化膦 | CAS号59626-33-4 2-(三溴甲磺酰基)吡啶 | CAS号20329-37-7 2-Methyl-6-(met... | CAS号19006-76-9 2-(Ethylthio)py... | CAS号366-18-7 2,2'-联吡啶 | CAS号101-82-6 2-苄基吡啶 | CAS号244-76-8 9H-吡啶并[2,3-B]吲哚 | CAS号5969-83-5 2-(4-氯苯基)吡啶 | CAS号694-85-9 1-甲基-2-吡啶酮 | CAS号4467-06-5 2-(对甲苯基)吡啶 | CAS号1008-89-5 2-苯基吡啶

2-(甲基亚硫酰基)吡啶置于四羟基二硼体系中,用 甲苯 用作溶剂,以99%的收率获得2-甲硫基吡啶
参考文献:使用 B2(Oh)4 作为脱氧剂,在无催化剂和添加剂的情况下将亚砜化学选择性还原为硫化物
标题:使用 B2(Oh)4 作为脱氧剂,在无催化剂和添加剂的情况下将亚砜化学选择性还原为硫化物
摘要:描述了一种在没有催化剂和添加剂的情况下使用四羟基二硼 [b 2 (Oh) 4 ] 作为脱氧剂将亚砜还原为硫化物的操作简单实用的方法.多种二芳基亚砜,二烷基亚砜和芳基/烷基亚砜成功转化为相应的硫化物,收率为 92-99%.通过36个实例和克级合成证明了其适用性和实用性.该工作拓展了b 2 (Oh) 4从芳环,羰基,烯烃,炔烃,亚胺,硝基化合物,卤化物到亚砜的还原反应的应用领域.
Doi:10.1016/j.Tet.2023.133411

专利信息

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).

专利号:US-8637434-B2
优先权日:1996-04-17
标题 :System for photolithographic synthesis of polymer arrays
发明人：GOLDBERG MARTIN J; DIGGELMAN MARTIN; HUBBELL EARL A; MCGALL GLENN H; NAM NGO; MORRIS MACDONALD S; YAMAMOTO MELVIN; TAN JENNIFER; RAVA RICHARD
权利人:AFFYMETRIX INC
摘要:The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.

专利号:US-2006183886-A1
优先权日:1995-11-22
标题:Ligands to enhance cellular uptake of biomolecules
发明人：TSO PAUL O; DUFF ROBERT; ZHOU YUANZHONG; DEAMOND SCOTT; ROBY CLINTON
权利人:CELL WORKS THERAPEUTICS INC A
摘要:The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or “payloadâ€? to a hepatocyte intracellularly via a receptor-mediated, ligand-directed pathway.

专利号:US-6989401-B2
优先权日:2000-07-19
标题:Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
发明人：MAEDA KAZUHIRO; SONDA SHUJI; TAKEMOTO TADAHIRO; GOTO TOMOKAZU; KOBAYASHI FUJIO; KAJII MASAHIKO; KOMORITA NARUYASU; HIRAYAMA FUMIHIRO
权利人:MITSUBISHI PHARMA CORP
摘要:The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.

专利号:WO-2011047481-A1
优先权日:2009-10-23
标题 :Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
权利人:MERCK FROSST CANADA LTD; FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl- coenzyme. A delta-9 desaturase (SCDl) relative to other known stearoyl-coenzyme. A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).

专利号:US-2023135188-A1
优先权日:2017-07-06
标题:Fe/cu-mediated ketone synthesis
发明人：KISHI YOSHITO; YAHATA KENZO; KUMAR VEMULA PRAVEEN; VADDELA SUDHEER BABU
权利人:HARVARD COLLEGE
摘要:Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated (“Fe/Cu-mediatedâ€?) coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins.