CAS: 27246-81-7; 3-Bromophenylhydrazine Hydrochloride

上下游产品

m-Bromoaniline 1,3-dibromobenzene 3-{1-[(3-Bromo-phenyl)-hydrazono]-ethyl}-4-hydroxy-chromen-2-one phenyl-(5-phenyl-[1,2,4]oxadiazol-3-yl)-methanone (3-bromo-phenyl)-hydrazone N-(3-Bromo-phenyl)-N'-[1-phenyl-1-(5-phenyl-[1,2,4]oxadiazol-3-yl)-meth-(Z)-ylidene]-hydrazine 1-(3-Bromo-phenyl)-5-(2-nitro-phenyl)-3-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

间溴苯胺置于盐酸,Sodium Nitrite,Tin(II) Chloride Dihdyrate体系中,用 水 用作溶剂,化学反应 3.0H,反应生成3-溴苯肼盐酸盐
参考文献:作为具有新型结合模式的 Pdhc-E1 抑制剂的 2,6-二甲基-4-氨基嘧啶腙的设计,合成和抗真菌活性
标题:作为具有新型结合模式的 Pdhc-E1 抑制剂的 2,6-二甲基-4-氨基嘧啶腙的设计,合成和抗真菌活性
摘要:一系列新型 2,6-二甲基-4-氨基嘧啶腙5被合理设计和合成为丙酮酸脱氢酶复合物 E1 (Pdhc-E1) 抑制剂.化合物5强烈抑制大肠杆菌(e.Coli)pdhc-E1(ic 50值为 0.94-15.80 μm).分子对接,定点诱变,酶促和抑制动力学分析表明,化合物5竞争性抑制 Pdhc-E1 并以"直线"模式结合在大肠杆菌pdhc-E1 活性位点,这是一种新的结合模式. 在体外抗真菌试验中,大多数化合物5在50μg/ Ml的显示针对六个测试植物病原性真菌,包括菌丝生长超过80%的抑制灰霉病,念珠菌fructigena,炭疽病菌,和葡萄座腔dothidea侵染.值得注意的是,5F和5I对m. Fructigena 的效力是商业杀菌剂克菌丹和百菌清的1.8-380 倍.在体内,与商业杀菌剂戊唑醇相比,5F和5I控制m. Fructigena的生长.因此,5F和5I对防治果蝇桃褐腐病具有潜在的商业价值.
Doi:10.1021/acs.Jafc.0C07701

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:US-2008096868-A1
优先权日:2004-11-12
标题:1,4 Substituted Pyrazolopyrimidines as Kinase Inhibitors
发明人：SCHMIEDEBERG NIKO; FURET PASCAL; IMBACH PATRICIA; HOLZER PHILIPP
权利人:SCHMIEDEBERG NIKO; FURET PASCAL; IMBACH PATRICIA; HOLZER PHILIPP
摘要:The invention relates to 1,4-substituted pyrazolopyrimidine compounds of the formula I, n npharmaceuticals comprising a 1,4-substituted pyrazolopyrimidine compound, the use of a 1,4-substituted pyrazolopyrimidine compound in the treatment or the use thereof in the manufacture of a pharmaceutical formulation for the treatment of a disease that depends on inadequate activity of a protein kinase, methods of treatment comprising administering a 1,4-substituted pyrazolopyrimidine compound, methods for the manufacture of a novel compound of that class, and novel intermediates and partial steps for their synthesis.

专利号:WO-2023057548-A1
优先权日:2021-10-07
标题:Ccr6 receptor modulators
发明人：AISSAOUI HAMED; ALLEMANN OLIVER; CAROFF EVA; MEYER EMMANUEL; RICHARD-BILDSTEIN SYLVIA
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

专利号:CN-107663161-B
优先权日:2016-07-27
标题:A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt

专利号:CN-107663161-A
优先权日:2016-07-27
标 题 :A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt