CAS: 36239-09-5; Ethyl Malonyl Chloride

上下游产品

CAS号1071-46-1 丙二酸单乙酯 | CAS号6148-64-7 丙二酸单乙酯钾盐 | CAS号105-53-3 丙二酸二乙酯 | CAS号88-95-9 邻苯二甲酰氯 | CAS号7719-09-7 氧氯化硫 | CAS号32864-38-3 丙二酸叔丁基乙酯 | CAS号54458-28-5 3-氧代-3-(2,4,6-三... | CAS号40059-53-8 2,4-二羟基喹啉-3-甲酸乙酯 | CAS号22316-45-6 乙酰基-5-氯-2-硝基二苯胺-N-乙酯 | CAS号252955-06-9 ETHYL 3-OXO-3-(... | CAS号29182-42-1 2-(2-苯并噻唑)乙酸乙酯 | CAS号28731-96-6 3-Oxo-3,4-dihyd... | CAS号850814-34-5 4-羟基-1-异戊基-2-氧代... | CAS号94-02-0 苯甲酰乙酸乙酯 | CAS号27835-00-3 (4-甲基苯甲酰基)乙酸乙酯

丙二酸单乙酯置于草酰氯体系中,用 二氯甲烷 用作溶剂,化学反应生成氯甲酰乙酸乙酯
参考文献:不对称转移氢化是合成氨基羧酸膦酸类似物的关键步骤
标题:不对称转移氢化是合成氨基羧酸膦酸类似物的关键步骤
摘要:17 α-氧代膦酸二异丙酯的不对称转移氢化(Ath)是通过使用市售的noyori型催化剂完成的.高度对映体富集的产物(除了一种情况外,在所有情况下ee > 98%)进一步转化为 15 种氨基羧酸的膦酸类似物.所建立的方法也可用于起始α-氧代膦酸酯的不对称转移氘代(atd).
Doi:10.1002/chem.202302171

专利信息

专利号:US-7358382-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

专利号:US-7368568-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人：WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:US-6686503-B2
优先权日:1999-04-14
标 题 :Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries
发明人：CHAI WENYING; MURRAY WILLIAM V
权利人:ORTHO MCNEIL PHARM INC
摘要:The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula:wherein R<1>, R<2 >and R<3 >are as herein described, novel intermediates useful for synthesizing such 2,4-dioxopiperidine compounds and methods for identifying and isolating the compounds.

专利号:US-2006084805-A1
优先权日:2004-09-30
标题:Synthesis of thienopyridinone compounds and related intermediates